Wtap Gene Summary [Mouse]
Predicted to enable identical protein binding activity. Predicted to be involved in mRNA processing and regulation of alternative mRNA splicing, via spliceosome. Located in cytoplasm and nucleoplasm. Part of RNA N6-methyladenosine methyltransferase complex. Is expressed in several structures, including early conceptus; embryo mesoderm; hemolymphoid system gland; hindlimb; and jaw epithelium. Orthologous to human WTAP (WT1 associated protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Wtap |
| Official Name | Wilms tumour 1-associating protein [Source:MGI Symbol;Acc:MGI:1926395] |
| Ensembl ID | ENSMUSG00000060475 |
| Bio databases IDs | |
| Aliases | Wilms tumour 1-associating protein |
| Synonyms | 2810408K05Rik, 9430038B09RIK, KIAA0105, Mum2, RGD1563824, WT1 associated protein, WT1 associating protein |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Wtap often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- WTAP/Mum2p family
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- diffuse large B-cell lymphoma
- nonalcoholic steatohepatitis
- B-cell non-Hodgkin disease
- mature B-cell neoplasia
- soft tissue sarcoma cancer
- organismal death
- liver cancer
- epithelial cancer
- rhabdomyosarcoma
role in cell
- expression in
- growth
- cellular infiltration by
- apoptosis
- phosphorylation in
- number
- differentiation
- migration
- proliferation
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- spliceosomes
- nucleoplasm
- nucleoli
- interchromatin granule clusters
- nuclear envelope
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Wtap gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing
- regulation of alternative nuclear mRNA splicing, via spliceosome
- mRNA processing
- mRNA modification
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear membrane
- cytoplasm
- nuclear speck
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding