Rps27a Gene Summary [Mouse]
Predicted to enable protein tag activity and ubiquitin protein ligase binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in modification-dependent protein catabolic process; protein ubiquitination; and ribosomal small subunit biogenesis. Located in myelin sheath. Is active in synapse. Orthologous to human RPS27A (ribosomal protein S27a). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Rps27a |
| Official Name | ribosomal protein S27A [Source:MGI Symbol;Acc:MGI:1925544] |
| Ensembl ID | ENSMUSG00000020460 |
| Bio databases IDs | |
| Aliases | ribosomal protein S27A |
| Synonyms | 0610006J14Rik, CEP80, eS31, HEL112, ribosomal protein S27A, S27A, Uba52, UBA80, Ubb, UBC, UBCEP1, UBCEP80 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rps27a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ubiquitin family
- structural constituent of ribosome
- Ubl1_cv_Nsp3_N-like
- Ribosomal protein S27a
- Ubiquitin homologues
- protein binding
Pathways
Biological processes and signaling networks where the Rps27a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- organismal death
- non-small cell lung cancer
- myelodysplastic syndrome
- lung adenocarcinoma
- lung adenocarcinoma formation
- non-small cell lung carcinoma
role in cell
- cell viability
- apoptosis
- binding in
- cell death
- replication in
- G1 phase
- ubiquitination in
- processing in
- nuclear export in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- endocytic vesicle membrane
- pre-ribosome
- ribosome
- Nucleus
- Plasma Membrane
- Endoplasmic Reticulum
- cytosol
- endoplasmic reticulum membrane
- mitochondrial outer membrane
- endosomal membrane
- nucleoplasm
- nucleoli
- synapse
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rps27a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytoplasmic translation
- modification-dependent protein catabolic process
- protein ubiquitination
- translation
Cellular Component
Where in the cell the gene product is active
- small-subunit processome
- cytosolic ribosome
- cytosolic small ribosomal subunit
- synapse
- mitochondrial outer membrane
- nucleolus
- plasma membrane
- nucleoplasm
- endoplasmic reticulum membrane
- nucleus
- extracellular space
- extracellular vesicular exosome
- cytoplasm
- membrane
- vesicle
- cytosol
- endosome membrane
- endocytic vesicle membrane
Molecular Function
What the gene product does at the molecular level
- ubiquitin protein ligase binding
- RNA binding
- protein binding
- structural constituent of ribosome
- metal ion binding
- protein tag