Lmbr1l Gene Summary [Mouse]
Predicted to enable transmembrane signaling receptor activity. Involved in several processes, including T cell activation; hematopoietic stem cell differentiation; and negative regulation of canonical Wnt signaling pathway. Located in endoplasmic reticulum membrane. Is expressed in several structures, including central nervous system; eye; genitourinary system; gut; and immune system. Orthologous to human LMBR1L (limb development membrane protein 1 like). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lmbr1l |
| Official Name | limb region 1 like [Source:MGI Symbol;Acc:MGI:1289247] |
| Ensembl ID | ENSMUSG00000022999 |
| Bio databases IDs | |
| Aliases | limb region 1 like |
| Synonyms | 1110013E13Rik, D15Ertd735e, limb development membrane protein 1-like, limb region 1 like, LIMR, RGD1309631 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lmbr1l often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- LMBR1-like membrane protein
- protein binding
- transmembrane receptor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
- LCN1
regulated by
disease
- osteoarthritis
phenotypes
- abnormal B cell differentiation
- abnormal CD4-positive T cell differentiation
- abnormal CD8-positive alpha-beta T cell differentiation
- abnormal T cell differentiation
- abnormal alpha-beta T cell morphology
- abnormal bone marrow cell morphology/development
- abnormal cytotoxic T cell physiology
- abnormal lymphocyte morphology
- decreased CD4-positive alpha beta T cell number
- decreased CD8-positive alpha-beta T cell number
- decreased CD8-positive naive alpha-beta T cell number
- decreased IgD level
- decreased IgE level
- decreased IgG level
- decreased IgM level
- decreased NK T cell number
- decreased NK cell number
- decreased T cell number
- decreased common lymphocyte progenitor cell number
- decreased dendritic cell number
- decreased leukocyte cell number
- decreased lymphocyte cell number
- decreased monocyte cell number
- impaired humoral immune response
- impaired natural killer cell mediated cytotoxicity
- increased B-1 B cell number
- increased IgM level
- increased central memory CD4-positive alpha-beta T cell number
- increased central memory CD8 positive alpha-beta T cell number
- increased effector memory CD4-positive alpha-beta T cell number
- increased hematopoietic cell number
- increased macrophage cell number
- increased neutrophil cell number
- no abnormal phenotype detected
role in cell
- proliferation
- apoptosis
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- plasma membrane fraction
- granules
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lmbr1l gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of canonical Wnt receptor signaling pathway
- T cell differentiation
- signal transduction
- T cell proliferation
- T cell apoptotic process
- hemopoietic stem cell differentiation
- Wnt receptor signaling pathway
- receptor-mediated endocytosis
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- transmembrane signaling receptor activity