Lmbr1l Gene Summary [Mouse]
Predicted to enable transmembrane signaling receptor activity. Involved in several processes, including T cell activation; hematopoietic stem cell differentiation; and negative regulation of canonical Wnt signaling pathway. Located in endoplasmic reticulum membrane. Is expressed in several structures, including central nervous system; eye; genitourinary system; gut; and immune system. Orthologous to human LMBR1L (limb development membrane protein 1 like). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lmbr1l |
| Official Name | limb region 1 like [Source:MGI Symbol;Acc:MGI:1289247] |
| Ensembl ID | ENSMUSG00000022999 |
| Bio databases IDs | |
| Aliases | limb region 1 like |
| Synonyms | 1110013E13Rik, D15Ertd735e, limb development membrane protein 1-like, limb region 1 like, LIMR, RGD1309631 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lmbr1l often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- LMBR1-like membrane protein
- protein binding
- transmembrane receptor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- plasma membrane fraction
- granules
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lmbr1l gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of canonical Wnt receptor signaling pathway
- T cell differentiation
- signal transduction
- T cell proliferation
- T cell apoptotic process
- hemopoietic stem cell differentiation
- Wnt receptor signaling pathway
- receptor-mediated endocytosis
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- transmembrane signaling receptor activity