NDUFC1

NDUFC1 Gene Summary

The encoded protein is a subunit of the NADH:ubiquinone oxidoreductase (complex I), the first enzyme complex in the electron transport chain located in the inner mitochondrial membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

Details

Type
Nonsense Mediated Decay
Official Symbol
NDUFC1
Official Name
NADH:ubiquinone oxidoreductase subunit C1 [Source:HGNC Symbol;Acc:HGNC:7705]
Ensembl ID
ENSG00000109390
Bio databases IDs NCBI: 4717 Ensembl: ENSG00000109390
Aliases NADH:ubiquinone oxidoreductase subunit C1, complex I KFYI subunit
Synonyms
2310016K22Rik,CI-KFYI,Complex I-KFYI,KFYI,LOC100364536,LOC679398,NADH:ubiquinone oxidoreductase subunit C1
Species
Human, Homo sapiens

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • enzyme
  • NADH2 dehydrogenase (ubiquinone)
  • NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial

Pathways

Biological processes and signaling networks where the NDUFC1 gene plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
  • PITX2
  • TNIP2
disease
  • insulin resistance
  • adrenal cortex carcinoma
  • adrenocortical carcinoma
  • Huntington disease
regulated by
  • lipopolysaccharide
  • arsenic trioxide
  • U0126
  • PTEN
  • IFNG
  • metribolone
  • betaine
  • Hbb-b1
  • imatinib
  • TSPO
regulates
role in cell

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • Mitochondria
  • mitochondrial inner membrane

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the NDUFC1 gene, providing context for its role in the cell.

BIOLOGICAL PROCESS

Functions and activities the gene product is involved in
  • transmembrane transport
  • mitochondrial electron transport, NADH to ubiquinone
  • mitochondrial respiratory chain complex I assembly
  • aerobic respiration
  • mitochondrial ATP synthesis coupled proton transport

CELLULAR COMPONENT

Where in the cell the gene product is active
  • respiratory chain complex I
  • mitochondrial inner membrane

MOLECULAR FUNCTION

What the gene product does at the molecular level
  • NADH dehydrogenase (ubiquinone) activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.