TNIP2 Gene Summary [Human]
This gene encodes a protein which acts as an inhibitor of NFkappaB activation. The encoded protein is also involved in MAP/ERK signaling pathway in specific cell types. It may be involved in apoptosis of endothelial cells. Alternative splicing results in multiple transcript variants. A pseudogene related to this gene is located on the X chromosome.[provided by RefSeq, May 2014]
Details
| Type | Protein Coding |
| Official Symbol | TNIP2 |
| Official Name | TNFAIP3 interacting protein 2 [Source:HGNC Symbol;Acc:HGNC:19118] |
| Ensembl ID | ENSG00000168884 |
| Bio databases IDs | |
| Aliases | TNFAIP3 interacting protein 2 |
| Synonyms | 1810020H16RIK, ABIN-2, FLIP1, KLIP, TNFAIP3 interacting protein 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TNIP2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase binding
- UBAN motif
- Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
- TSG101 and ALIX binding domain of CEP55
- protein binding
- zinc finger domain
Pathways
Biological processes and signaling networks where the TNIP2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- systemic lupus erythematosus
- B-cell non-Hodgkin disease
- mature B-cell neoplasia
- airway inflammation
- diffuse large B-cell lymphoma
role in cell
- cell viability
- apoptosis
- generation in
- activation in
- activation
- survival
- autophosphorylation in
- function
- response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TNIP2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- toll-like receptor 9 signaling pathway
- toll-like receptor 2 signaling pathway
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
- CD40 signaling pathway
- inflammatory response
- positive regulation of B cell activation
- cellular response to lipopolysaccharide
- positive regulation of macrophage activation
- apoptotic process
- toll-like receptor 3 signaling pathway
- interleukin-1-mediated signaling pathway
- negative regulation of endothelial cell apoptotic process
- protein stabilization
Cellular Component
Where in the cell the gene product is active
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- polyubiquitin binding
- K63-linked polyubiquitin binding
- metal ion binding