F8 Gene Summary [Rat]
Predicted to enable copper ion binding activity and oxidoreductase activity. Involved in blood coagulation, intrinsic pathway. Located in extracellular space. Used to study factor VIII deficiency; hemarthrosis; and hyperhomocysteinemia. Human ortholog(s) of this gene implicated in factor VIII deficiency. Orthologous to human F8 (coagulation factor VIII). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | F8 |
| Official Name | coagulation factor VIII [Source:RGD Symbol;Acc:727845] |
| Ensembl ID | ENSRNOG00000031197 |
| Bio databases IDs | |
| Aliases | coagulation factor VIII |
| Synonyms | AHF, antihemophilic factor, biostate, Cf-8, coagulation factor VIII, coagulation factor VIII, procoagulant component (haemophilia A) protein, human, DXS1253E, F8B, F8C, FACTOR VIII A1, factor VIIIC, factor VIII clotting antigen, factor VIII coagulant antigen, FVIII, F VIII-C, haemate HS, HEMA, monoclate, octocog alfa, THPH13, thromboplastinogen |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat F8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Multicopper oxidase
- constant light chain domain
- F8 type B domain
- Coagulation factor 5/8 C-terminal domain, discoidin domain
- fVIII A3 domain
- variable heavy chain
- A2 domain
- protein binding
- phospholipid binding domain
- acidic domain
- fVIII C1 domain
- fVIII A1 domain
- Cupredoxin superfamily
- F5/8 type C domain
- BiP binding domain
- fVIII C2 domain
- fVIII ap domain
- FA58C
Pathways
Biological processes and signaling networks where the F8 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection
- epithelial cancer
- sepsis
- hepatocellular carcinoma
- liver cancer
- COVID-19
- hemophilia B
- heparin-induced thrombocytopenia
- von Willebrand disease type 2M
- hemophilia A
role in cell
- expression in
- binding
- memory immune response
- production
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Golgi lumen
- Cytoplasm
- cellular membrane
- Nucleus
- Plasma Membrane
- endoplasmic reticulum lumen
- alpha granules
- transport vesicles
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat F8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- blood coagulation, intrinsic pathway
- blood coagulation
- acute-phase response
Cellular Component
Where in the cell the gene product is active
- platelet alpha granule lumen
- endoplasmic reticulum lumen
- extracellular space
- ER to Golgi transport vesicle
- extracellular region
- Golgi lumen
- plasma membrane
- endoplasmic reticulum-Golgi intermediate compartment membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- copper ion binding
- oxidoreductase activity