Il2ra Gene Summary [Rat]
Enables interleukin-2 receptor activity. Involved in inflammatory response to antigenic stimulus; positive regulation of T cell differentiation; and positive regulation of T cell proliferation. Located in cell surface. Used to study Korean hemorrhagic fever; asthma; and diabetes mellitus. Human ortholog(s) of this gene implicated in immunodeficiency 41; lymphopenia; multiple sclerosis; type 1 diabetes mellitus; and type 1 diabetes mellitus 10. Orthologous to human IL2RA (interleukin 2 receptor subunit alpha). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Il2ra |
| Official Name | interleukin 2 receptor subunit alpha [Source:RGD Symbol;Acc:2895] |
| Ensembl ID | ENSRNOG00000047647 |
| Bio databases IDs | |
| Aliases | interleukin 2 receptor subunit alpha |
| Synonyms | CD25, IDDM10, IL2R, IL2RAC, Il 2 receptor α subunit, Il2r α, IMD41, interleukin 2 receptor, alpha chain, interleukin 2 receptor subunit alpha, interleukin 2 receptor subunit α, interleukin 2 receptor α, Interleukin 2 receptor α chain, interleukin 2 receptor, α chain, Ly-43, p55, TAC, TAC ANTIGEN, TCGFR |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Il2ra often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CCP
- extracellular domain
- Shc binding site
- cytoplasmic domain
- ectodomain
- transmembrane domain
- protein binding
- cytosolic tail domain
- transmembrane receptor
- SUSHI repeat
- interleukin-2 receptor
- interleukin-2 binding
Pathways
Biological processes and signaling networks where the Il2ra gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- acute myeloid leukemia
- ulcerative colitis
- dermatological disorder
- epithelial cancer
- renal clear cell adenocarcinoma
- high risk neuroblastoma
- leukemia
- vitiligo vulgaris
- rheumatoid arthritis
role in cell
- growth
- proliferation
- differentiation
- apoptosis
- expression in
- quantity
- activation
- cell death
- survival
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- plasma membrane extracellular face
- apical membrane
- perinuclear space
- membrane rafts
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Il2ra gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- interleukin-2-mediated signaling pathway
- negative regulation of inflammatory response
- cell surface receptor signaling pathway
- positive regulation of activated T cell proliferation
- regulation of T cell tolerance induction
- activation-induced cell death of T cells
- inflammatory response
- immune response
- Notch signaling pathway
- inflammatory response to antigenic stimulus
- regulation of T cell homeostatic proliferation
- negative regulation of T cell proliferation
- positive regulation of T cell differentiation
- apoptotic process
- regulation of CD4-positive, alpha-beta T cell proliferation
- activated T cell proliferation
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- interleukin-2 receptor complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- interleukin-2 receptor activity
- protein binding
- interleukin-2 binding