Lama2 Gene Summary [Mouse]
Predicted to be an extracellular matrix structural constituent. Acts upstream of or within axon guidance and positive regulation of cholinergic synaptic transmission. Located in basement membrane and sarcolemma. Is active in neuromuscular junction and synaptic cleft. Is expressed in several structures, including alimentary system; extracellular matrix; metanephros; musculature; and nervous system. Used to study congenital merosin-deficient muscular dystrophy 1A. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy; congenital merosin-deficient muscular dystrophy 1A; muscular dystrophy; and myopia. Orthologous to human LAMA2 (laminin subunit alpha 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Lama2 |
| Official Name | laminin, alpha 2 [Source:MGI Symbol;Acc:MGI:99912] |
| Ensembl ID | ENSMUSG00000019899 |
| Bio databases IDs | |
| Aliases | laminin, alpha 2 |
| Synonyms | 5830440B04, dy, laminin, alpha 2, Laminin M, Laminin M chain, laminin subunit alpha 2, laminin subunit α 2, Laminin α 2, laminin, α 2, LAMM, MDC1A, mer, merosin, mKIAA4087 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lama2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Phage minor structural protein GP20
- Laminin B (Domain IV)
- Synaptonemal complex protein 1 (SCP-1)
- Coiled-coiled domain of autophagy-related 16 (Atg16) family proteins
- Autophagy protein ATG17-like domain
- helix-rich Mycoplasma protein
- Tektin family
- Laminin Domain II
- EGF_CA
- Laminin Domain I
- Laminin-type epidermal growth factor-like domai
- Tropomyosin
- Chromatin assembly factor 1 complex p150 subunit, N-terminal
- Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
- HOOK protein coiled-coil region
- laminin G domain
- SPEC
- Laminin N-terminal (Domain VI)
- Giardia variant-specific surface protein
- Weak chloroplast movement under blue light
- LamG
- Tropomyosin like
- Ezrin/radixin/moesin, alpha-helical domain
- 4-helix bundle ligand binding sensor domain of chemoreceptors such as Tar or Tsr
- Four helix bundle sensory module for signal transduction
- Domain of unknown function (DUF4795)
- protein binding
- Tumor necrosis factor receptor superfamily (TNFRSF)
- SF-assemblin/beta giardin
- laminin-G repeat
- Spectrin repeats
- Mechanosensitive ion channel porin domain
- Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer)
- Methyl-accepting chemotaxis protein (MCP), signaling domain
- ClyA-like
- structural molecule
- Apolipoprotein A1/A4/E domain
- Laminin EGF domain
Pathways
Biological processes and signaling networks where the Lama2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- uterine leiomyoma
- pain
- neoplasia
- congenital muscular dystrophy due to merosin deficiency
- refractive error
- autosomal recessive limb-girdle muscular dystrophy type 23
- LAMA2 related muscular dystrophy
- hyperopia
- hereditary disorder
- schizophrenia
phenotypes
- abnormal Schwann cell morphology
- abnormal axon radial sorting
- abnormal axonal transport
- abnormal basal lamina morphology
- abnormal basement membrane morphology
- abnormal bony labyrinth
- abnormal cochlear hair cell morphology
- abnormal cochlear nerve morphology
- abnormal cranium morphology
- abnormal gait
- abnormal galactolipid level
- abnormal inner ear vestibule morphology
- abnormal joint morphology
- abnormal lipid level
- abnormal motor capabilities/coordination/movement
- abnormal motor coordination/ balance
- abnormal muscle physiology
- abnormal muscle regeneration
- abnormal myelination
- abnormal organ of Corti morphology
- abnormal organ of Corti supporting cell morphology
- abnormal reflex
- abnormal sarcolemma morphology
- abnormal seminiferous tubule morphology
- abnormal sexual interaction
- abnormal skeletal muscle fiber morphology
- abnormal skeletal muscle morphology
- abnormal skeletal muscle regeneration
- abnormal spermatid morphology
- abnormal testis morphology
- abnormal thymus corticomedullary boundary morphology
- abnormal thymus physiology
- absent cochlear hair cells
- absent vestibular hair cells
- ataxia
- cachexia
- centrally nucleated skeletal muscle fibers
- cochlear degeneration
- decreased T cell number
- decreased aggression
- decreased body size
- decreased body weight
- decreased brain weight
- decreased double-positive T cell number
- decreased nerve conduction velocity
- decreased skeletal muscle fiber number
- decreased spinal cord weight
- decreased testis weight
- demyelination
- dystrophic muscle
- enhanced long term potentiation
- hindlimb paralysis
- hypoactivity
- increased IgG level
- increased IgM level
- increased cholesterol level
- increased circulating prolactin level
- increased cranium width
- increased or absent threshold for auditory brainstem response
- increased variability of skeletal muscle fiber size
- joint contracture
- kyphoscoliosis
- kyphosis
- limb grasping
- muscle degeneration
- muscle spasm
- muscle weakness
- myopathy
- myositis
- opisthotonus
- paresis
- perinatal lethality incomplete penetrance
- postnatal growth retardation
- postnatal lethality incomplete penetrance
- premature death
- progressive muscle weakness
- reduced long term depression
- scoliosis
- skeletal muscle endomysial fibrosis
- skeletal muscle fiber necrosis
- skeletal muscle interstitial fibrosis
- stria vascularis degeneration
- tachypnea
- thymus cortex hypoplasia
role in cell
- growth
- phosphorylation in
- activation
- migration
- proliferation
- number
- accumulation
- apoptosis
- formation
- binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- perisynaptic region
- Plasma Membrane
- dendritic spines
- neuromuscular junctions
- nerve ending
- synapse
- sarcolemma
- extracellular matrix
- basal lamina
- axon terminals
- plasma
- basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lama2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- Schwann cell differentiation
- muscle organ development
- regulation of embryonic development
- axon guidance
- positive regulation of synaptic transmission, cholinergic
- cell adhesion
- positive regulation of cell adhesion
- regulation of cell migration
- positive regulation of integrin-mediated signaling pathway
- maintenance of blood-brain barrier
- positive regulation of muscle cell differentiation
Cellular Component
Where in the cell the gene product is active
- basement membrane
- synaptic cleft
- sarcolemma
- dendritic spine
- neuromuscular junction
- extracellular region
Molecular Function
What the gene product does at the molecular level
- structural molecule activity
- extracellular matrix structural constituent
- receptor binding