Naa10 Gene Summary [Mouse]
Enables N-acetyltransferase activity. Predicted to be involved in N-terminal protein amino acid acetylation and negative regulation of maintenance of mitotic sister chromatid cohesion, centromeric. Located in cytoplasm. Is expressed in several structures, including brain; genitourinary system; heart; liver; and submandibular gland primordium. Human ortholog(s) of this gene implicated in Ogden syndrome and syndromic microphthalmia 1. Orthologous to human NAA10 (N-alpha-acetyltransferase 10, NatA catalytic subunit). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Naa10 |
| Official Name | N(alpha)-acetyltransferase 10, NatA catalytic subunit [Source:MGI Symbol;Acc:MGI:1915255] |
| Ensembl ID | ENSMUSG00000031388 |
| Bio databases IDs | |
| Aliases | N(alpha)-acetyltransferase 10, NatA catalytic subunit |
| Synonyms | 2310039H09Rik, ANOP1, ARD1, ARD1A, ARD1P, DXS707, hARD1, LZMS, MAA, MCOPS1, N-alpha-acetyltransferase 10, NatA catalytic subunit, N(alpha)-acetyltransferase 10, NatA catalytic subunit, NATD, N-α-acetyltransferase 10, NatA catalytic subunit, N(α)-acetyltransferase 10, NatA catalytic subunit, OGDNS, RGD1565315, TE2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Naa10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Acetyltransferase (GNAT) family
- N-acetyltransferase
- peptide alpha-N-acetyltransferase
- NAT_SF
- ribosome binding
- Acetyltransferase (GNAT) domain
- enzyme
- protein binding
- acetyltransferase
Pathways
Biological processes and signaling networks where the Naa10 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- neurodevelopmental disorder
- obesity
- mental retardation
- congenital urogenital anomaly
- Ogden syndrome
- Lenz microphthalmia syndrome
- hydrocephalus
- NAA10 related N-terminal acetyltransferase deficiency
- esophageal adenocarcinoma
role in cell
- expression in
- proliferation
- differentiation
- function
- invasion by
- replication in
- number
- organization
- aggregation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Naa10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of maintenance of mitotic sister chromatid cohesion, centromeric
- chromosome organization
- internal protein amino acid acetylation
- protein acetylation
- N-terminal protein amino acid acetylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- NatA complex
- cytoplasm
- membrane
- cytosol
- nucleolus
Molecular Function
What the gene product does at the molecular level
- protein binding
- acetyltransferase activity
- ribosome binding
- peptide alpha-N-acetyltransferase activity
- N-acetyltransferase activity