SSH2
SSH2 Gene Summary
This gene encodes a protein tyrosine phosphatase that plays a key role in the regulation of actin filaments. The encoded protein dephosphorylates and activates cofilin, which promotes actin filament depolymerization. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Details
| Type | Protein Coding |
| Official Symbol | SSH2 |
| Official Name | slingshot protein phosphatase 2 [Source:HGNC Symbol;Acc:HGNC:30580] |
| Ensembl ID | ENSG00000141298 |
| Bio databases IDs | |
| Aliases | slingshot protein phosphatase 2 |
| Synonyms | BB104748,BC030940,mSSH-2L,slingshot protein phosphatase 2,SSH-2L |
| Species | Human, homo_sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Dual specificity phosphatase, catalytic domain
- protein phosphatase
- actin binding
- phosphatase
- DEK C terminal domain
- protein binding
- PTP_DSP_cys
Pathways
Biological processes and signaling networks where the SSH2 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- TMOD3
- PRNP
- HECTD1
- MYCBP2
- CFL1
- ELAVL1
- KIF20A
- KCTD13
- YWHAH
- ACTB
disease
- insomnia
- nonalcoholic fatty liver disease
- metabolic syndrome X
- chronic obstructive pulmonary disease
regulated by
- E1
- isobutylmethylxanthine
- PDK1
- GPR174
- NSC23766
- AGT
- rolipram
- cilostamide
- mir-132 (includes others)
regulates
- actin
- LAMC2
- CFL1
- SSH1
- cofilin
- caspase 3/7
- F Actin
- SSH3
- Cfl1
role in cell
- expression in
- phosphorylation in
- migration
- G2/M phase
- accumulation in
- organization
- G1 phase
- accumulation
- polarity
- S phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- focal adhesions
- actin cytoskeleton
- actin filaments
- actin bundles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the SSH2 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- negative regulation of actin filament polymerization
- spermatogenesis
- protein dephosphorylation
- cell differentiation
- actin cytoskeleton organization
CELLULAR COMPONENT
Where in the cell the gene product is active
- extracellular space
- cytoskeleton
- focal adhesion
- cytoplasm
- acrosomal vesicle
MOLECULAR FUNCTION
What the gene product does at the molecular level
- phosphoprotein phosphatase activity
- actin binding
- protein tyrosine phosphatase activity
- myosin phosphatase activity