HECTD1 Gene Summary [Human]
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in anatomical structure development; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; and protein K63-linked ubiquitination. Predicted to act upstream of or within several processes, including animal organ development; negative regulation of protein localization to plasma membrane; and protein autoubiquitination. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | HECTD1 |
| Official Name | HECT domain E3 ubiquitin protein ligase 1 [Source:HGNC Symbol;Acc:HGNC:20157] |
| Ensembl ID | ENSG00000092148 |
| Bio databases IDs | |
| Aliases | HECT domain E3 ubiquitin protein ligase 1 |
| Synonyms | A630086P08RIK, AI844876, b2b327Clo, EULIR, HECT domain E3 ubiquitin protein ligase 1, Opm, RGD1561653 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HECTD1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Mib_herc2
- HECTc
- Ankyrin repeats (many copies)
- Sad1 / UNC-like C-terminal
- ubiquitin protein ligase activity
- basic tilted helix bundle (BTHB) domain
- Domain Homologous to E6-AP Carboxyl Terminus with
- Ankyrin repeats (3 copies)
- enzyme
- protein binding
- Ankyrin repeat
- ankyrin repeats
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- glioblastoma
- glioblastoma cancer
- exencephaly
- congenital heart disease
- nonalcoholic fatty liver disease
- T acute lymphoblastic leukemia
role in cell
- expression in
- invasion by
- migration
- proliferation
- binding in
- signaling in
- accumulation
- differentiation
- replication in
- emigration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HECTD1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- heart valve development
- aorta development
- ventricular septum development
- anatomical structure development
- protein K63-linked ubiquitination
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nuclear speck
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding