CXCL5
CXCL5 Gene Summary
This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils, to promote angiogenesis and to remodel connective tissues. This protein is thought to play a role in cancer cell proliferation, migration, and invasion. [provided by RefSeq, May 2013]
Details
| Type | Protein Coding |
| Official Symbol | CXCL5 |
| Official Name | C-X-C motif chemokine ligand 5 [Source:HGNC Symbol;Acc:HGNC:10642] |
| Ensembl ID | ENSG00000163735 |
| Bio databases IDs | |
| Aliases | C-X-C motif chemokine ligand 5 |
| Synonyms | C-X-C motif chemokine ligand 5,ENA-78,SCYB5 |
| Species | Human, homo_sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- chemokine
- Small cytokines (intecrine/chemokine), interleukin-8 like
- protein binding
- cytokine
- identical protein binding
Pathways
Biological processes and signaling networks where the CXCL5 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- SP1
- MEOX2
- CCL11
- CXCR2
- TMEM131
- XCL2
- SATB2
- PIGR
- PLAG1
- EFEMP2
disease
- rectum cancer
- squamous cell lung cancer
- pancreatic adenocarcinoma
- epithelial neoplasia
- chronic kidney disease
- metastasis
- cancer
- rheumatoid arthritis
- severe preeclampsia
- hyperzincemia and hypercalprotectinemia autoinflammatory syndrome
regulated by
- IL17F
- IFNG
- IL17A
- interferon alpha
- monocyte-derived macrophages
- IL1B
- TLR4
- ARID5A
- lipopolysaccharide
- TNF
regulates
- EGFR
- Ca2+
- TNF
- ERK
- CDH1
- ELK1
- ACTA2
- collagen alpha1
- DNA promoter
- DNA endogenous promoter
role in cell
- activation
- growth
- expression in
- phosphorylation in
- epithelial-mesenchymal transition
- invasion by
- migration
- activation in
- proliferation
- chemoattraction
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- soluble fraction
- cell surface
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the CXCL5 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- chemotaxis
- inflammatory response
- cellular response to lipopolysaccharide
- signal transduction
- chemokine-mediated signaling pathway
- positive regulation of cell proliferation
- cell-cell signaling
- neutrophil chemotaxis
CELLULAR COMPONENT
Where in the cell the gene product is active
- extracellular space
- extracellular region
MOLECULAR FUNCTION
What the gene product does at the molecular level
- identical protein binding
- protein binding
- CXCR chemokine receptor binding
- chemokine activity