PIGR Gene Summary [Human]
This gene is a member of the immunoglobulin superfamily. The encoded poly-Ig receptor binds polymeric immunoglobulin molecules at the basolateral surface of epithelial cells; the complex is then transported across the cell to be secreted at the apical surface. A significant association was found between immunoglobulin A nephropathy and several SNPs in this gene.[provided by RefSeq, Sep 2009]
Details
| Type | Protein Coding |
| Official Symbol | PIGR |
| Official Name | polymeric immunoglobulin receptor [Source:HGNC Symbol;Acc:HGNC:8968] |
| Ensembl ID | ENSG00000162896 |
| Bio databases IDs | |
| Aliases | polymeric immunoglobulin receptor |
| Synonyms | HEPATOCELLULAR CARCINOMA-ASSOCIATED protein TB6, Phosphatidylinositol glycan class r, pIgA-R, Polymeric immunoglobulin receptor, RNPIGR2, Sc |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PIGR often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- Fc receptor
- Immunoglobulin V-Type
- immunoglobulin domain
- epidermal growth factor receptor binding
- immunoglobulin binding
- ectoplasmic domain
- ligand-binding domain
- transmembrane domain
- Immunoglobulin like
- basolateral sorting signal
- Immunoglobulin V-set domain
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection by Salmonella enterica subsp. enterica serovar Typhimurium
- breast cancer
- endometrioma
- Sjögren syndrome
- non-small cell lung carcinoma
- non-small cell lung cancer
- autosomal dominant polycystic kidney disease
- Sjogren syndrome keratoconjunctivitis sicca
- infection by parasite
- infection by bacteria
role in cell
- number
- activation in
- proliferation
- invasion by
- migration
- cell death
- binding
- invasion
- adhesion
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- cell surface
- Extracellular Space
- apical compartment
- perinuclear region
- cellular membrane
- endosomes
- vesicles
- secretory granule membrane
- basolateral cell surfaces
- apical membrane
- Golgi membrane
- lysosome membrane
- endosomal membrane
- transport vesicles
- exosomes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PIGR gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor
- epidermal growth factor receptor signaling pathway
- detection of chemical stimulus involved in sensory perception of bitter taste
- receptor clustering
- Fc receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- secretory IgA immunoglobulin complex
- receptor complex
- azurophil granule membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- transmembrane signaling receptor activity
- polymeric immunoglobulin binding
- polymeric immunoglobulin receptor activity