PLAG1 Gene Summary [Human]
Pleomorphic adenoma gene 1 encodes a zinc finger protein with 2 putative nuclear localization signals. PLAG1, which is developmentally regulated, has been shown to be consistently rearranged in pleomorphic adenomas of the salivary glands. PLAG1 is activated by the reciprocal chromosomal translocations involving 8q12 in a subset of salivary gland pleomorphic adenomas. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | PLAG1 |
| Official Name | PLAG1 zinc finger [Source:HGNC Symbol;Acc:HGNC:9045] |
| Ensembl ID | ENSG00000181690 |
| Bio databases IDs | |
| Aliases | PLAG1 zinc finger |
| Synonyms | PLAG1 zinc finger, pleiomorphic adenoma gene 1, PSA, SGPA, SRS4, ZNF912 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PLAG1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- nucleic acid binding
- double-stranded DNA binding
- Zinc-finger double domain
- nuclear localization sequence
- zinc finger domain
- sequence-specific DNA binding
- transcription factor activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myeloid leukemia
- neoplasia
- adenoma formation
- soft tissue sarcoma cancer
- Russell-Silver syndrome
- hereditary disorder
- mental retardation
- gastrointestinal neoplasia
- Silver-Russell syndrome type 4
- mature T-cell neoplasia
role in cell
- proliferation
- growth
- contact growth inhibition
- expansion
- G1/S phase transition
- transcription in
- self-renewal
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- centrosome
- cytosol
- nucleoplasm
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PLAG1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- multicellular organism growth
- negative regulation of gene expression
- positive regulation of gene expression
- positive regulation of glial cell proliferation
- regulation of transcription, DNA-dependent
- gland morphogenesis
- prostate gland growth
- positive regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- centrosome
- nuclear speck
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity