CCL27
CCL27 Gene Summary
This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene is chemotactic for skin-associated memory T lymphocytes. This cytokine may also play a role in mediating homing of lymphocytes to cutaneous sites. It specifically binds to chemokine receptor 10 (CCR10). Studies of a similar murine protein indicate that these protein-receptor interactions have a pivotal role in T cell-mediated skin inflammation. [provided by RefSeq, Sep 2014]
Details
| Type | Processed Transcript |
| Official Symbol | CCL27 |
| Official Name | C-C motif chemokine ligand 27 [Source:HGNC Symbol;Acc:HGNC:10626] |
| Ensembl ID | ENSG00000213927 |
| Bio databases IDs | |
| Aliases | C-C motif chemokine ligand 27, CC chemokine ILC, IL-11 Ralpha-locus chemokine, cutaneous T-cell attracting chemokine |
| Synonyms | ALP,AW558992,CCL27A,CCL27B,C-C motif chemokine ligand 27,C-C motif chemokine ligand 27A,CTACK,CTAK,ESKINE,ILC,LOC545608,PESKY,SCYA27,Scya27a |
| Species | Human, homo_sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CCR chemokine receptor binding
- chemokine
- Small cytokines (intecrine/chemokine), interleukin-8 like
- protein binding
- cytokine
Pathways
Biological processes and signaling networks where the CCL27 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- CCR10
- PF4V1
- SELPLG
- LGALS3
- CCL5
- heparin
- TFAP2A
- RBPJ
- CCL11
- ACKR4
disease
- squamous cell cancer
- psoriasis
- pruritus
- Alzheimer disease
- skin basal cell carcinoma
- basal cell skin cancer
- squamous-cell carcinoma
- atopic dermatitis
- actinic keratosis
- sarcoidosis
regulated by
- IFNG
- lipopolysaccharide
- D-glucose
- TGFB1
- TNF
- IL1B
- simvastatin
- EGF
- ERK1/2
- erlotinib
regulates
- AKT
- Ca2+
- CCL18
role in cell
- growth
- migration
- apoptosis
- chemotaxis
- binding
- recruitment
- organization
- rearrangement
- reorganization
- extravasation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- perinuclear region
- Nucleus
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the CCL27 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- chemotaxis
- immune response
- signal transduction
- cell-cell signaling
- cell chemotaxis
CELLULAR COMPONENT
Where in the cell the gene product is active
- extracellular space
- extracellular region
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein binding
- CCR3 chemokine receptor binding
- chemokine activity