PF4V1 Gene Summary [Human]
The protein encoded by this gene is a chemokine that is highly similar to platelet factor 4. The encoded protein displays a strong antiangiogenic function and is regulated by chemokine (C-X-C motif) receptor 3. This protein also impairs tumor growth and can protect against blood-retinal barrier breakdown in diabetes patients. [provided by RefSeq, Nov 2015]
Details
| Type | Protein Coding |
| Official Symbol | PF4V1 |
| Official Name | platelet factor 4 variant 1 [Source:HGNC Symbol;Acc:HGNC:8862] |
| Ensembl ID | ENSG00000109272 |
| Bio databases IDs | |
| Aliases | platelet factor 4 variant 1 |
| Synonyms | CXCL4L1, CXCL4V1, PF4A, PF4-ALT, platelet factor 4 variant 1, SCYB4V1 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PF4V1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- chemokine
- Small cytokines (intecrine/chemokine), interleukin-8 like
- protein binding
- cytokine
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- Plasma Membrane
- Golgi Apparatus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PF4V1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inflammatory response
- cellular response to lipopolysaccharide
- chemokine-mediated signaling pathway
- neutrophil chemotaxis
Cellular Component
Where in the cell the gene product is active
- extracellular space
Molecular Function
What the gene product does at the molecular level
- protein binding
- CXCR chemokine receptor binding
- heparin binding
- chemokine activity