ACKR4 Gene Summary [Human]
The protein encoded by this gene is a member of the G protein-coupled receptor family, and is a receptor for C-C type chemokines. This receptor has been shown to bind dendritic cell- and T cell-activated chemokines including CCL19/ELC, CCL21/SLC, and CCL25/TECK. A pseudogene of this gene is found on chromosome 6. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2013]
Details
| Type | Protein Coding |
| Official Symbol | ACKR4 |
| Official Name | atypical chemokine receptor 4 [Source:HGNC Symbol;Acc:HGNC:1611] |
| Ensembl ID | ENSG00000129048 |
| Bio databases IDs | |
| Aliases | atypical chemokine receptor 4 |
| Synonyms | A630091E18Rik, atypical chemokine receptor 4, CCBP2, CC-CKR-11, CCR10, CCR-11, CCRL1, CCX-CKR, CCX-CKR1, CKR-11, Cmkbrl1, LOC684092, PPR1, VSHK1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ACKR4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Cholecystokinin A receptor, N-terminal
- chemokine receptor
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the ACKR4 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- atopic dermatitis
- hyperplasia
- Hutchinson-Gilford progeria syndrome
- experimental autoimmune encephalomyelitis
regulates
- CCL21
- chemokine
- ligand
role in cell
- activation in
- proliferation
- migration
- quantity
- number
- function
- degradation in
- abnormal number
- internalization in
- chemotaxis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ACKR4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chemotaxis
- immune response
- vesicle-mediated transport
- G-protein coupled receptor signaling pathway
- chemokine-mediated signaling pathway
- calcium-mediated signaling
- elevation of cytosolic calcium ion concentration
- cell chemotaxis
Cellular Component
Where in the cell the gene product is active
- early endosome
- external side of plasma membrane
- recycling endosome
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- C-C chemokine binding
- protein binding
- C-C chemokine receptor activity
- scavenger receptor activity
- chemokine receptor activity