AFAP1L1 Gene Summary [Human]
Predicted to enable SH3 domain binding activity. Predicted to be located in cell junction; cell projection; and podosome. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Retained Intron |
| Official Symbol | AFAP1L1 |
| Official Name | actin filament associated protein 1 like 1 [Source:HGNC Symbol;Acc:HGNC:26714] |
| Ensembl ID | ENSG00000157510 |
| Bio databases IDs | |
| Aliases | actin filament associated protein 1 like 1 |
| Synonyms | actin filament associated protein 1-like 1, FLJ36748, RGD1311580 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human AFAP1L1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PH domain
- protein binding
- Pleckstrin homology-like domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- metastasis
- organismal death
- chronic obstructive pulmonary disease
- spindle cell sarcoma
- central nervous system cancer
- gastric cancer
- neoplastic cell transformation
- primary central nervous system lymphoma
role in cell
- migration
- expression in
- recruitment in
- invasion
- formation
- formation in
- growth
- invasion by
- morphology
- migration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human AFAP1L1 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- anchoring junction
- stress fiber
- cytosol
- cell projection
- podosome
Molecular Function
What the gene product does at the molecular level
- protein binding
- SH3 domain binding