YWHAG Gene Summary [Human]
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the rat ortholog. It is induced by growth factors in human vascular smooth muscle cells, and is also highly expressed in skeletal and heart muscles, suggesting an important role for this protein in muscle tissue. It has been shown to interact with RAF1 and protein kinase C, proteins involved in various signal transduction pathways. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | YWHAG |
| Official Name | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma [Source:HGNC Symbol;Acc:HGNC:12852] |
| Ensembl ID | ENSG00000170027 |
| Bio databases IDs | |
| Aliases | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma, 14-3-3 gamma, protein phosphatase 1, regulatory subunit 170 |
| Synonyms | 14-3-3G, 14-3-3GAMMA, 14-3-3 γ, D7Bwg1348e, DEE56, EIEE56, PPP1R170, Similar to ywhag, Tyrosine 3-monooxygenase, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein γ, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, γ, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, γ polypeptide |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human YWHAG often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- receptor tyrosine kinase binding
- 14-3-3 domain
- actin binding
- protein kinase C binding
- 14-3-3 protein
- protein domain specific binding
- protein binding
- enzyme regulator activity
- identical protein binding
- insulin-like growth factor receptor binding
Pathways
Biological processes and signaling networks where the YWHAG gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- multiple sclerosis
- pancreatic cancer
- epithelial cancer
- hepatocellular carcinoma
- liver cancer
- schizophrenia
- hereditary disorder
- early infantile epileptic encephalopathy type 56
- Parkinson disease
- neonatal late-onset sepsis
role in cell
- expression in
- phosphorylation in
- cell death
- proliferation
- invasion by
- activation in
- accumulation in
- growth
- activation
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- presynaptic regions
- postsynaptic region
- Nucleus
- Plasma Membrane
- vesicles
- lipid droplets
- cytosol
- mitochondrial matrix
- synaptic vesicles
- growth cone
- synaptosomes
- synapse
- sarcolemma
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human YWHAG gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to insulin stimulus
- protein targeting
- signal transduction
- regulation of synaptic plasticity
- protein localization
- regulation of neuron differentiation
- regulation of signal transduction
- negative regulation of protein kinase activity
- cellular response to glucose starvation
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- focal adhesion
- cytoplasm
- membrane
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein kinase C binding
- identical protein binding
- protein domain specific binding
- RNA binding
- protein binding
- protein kinase C inhibitor activity
- receptor tyrosine kinase binding
- insulin-like growth factor receptor binding