VIRMA Gene Summary [Human]
Enables RNA binding activity. Involved in mRNA alternative polyadenylation and mRNA methylation. Located in cytosol and nuclear speck. Colocalizes with RNA N6-methyladenosine methyltransferase complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | VIRMA |
| Official Name | vir like m6A methyltransferase associated [Source:HGNC Symbol;Acc:HGNC:24500] |
| Ensembl ID | ENSG00000164944 |
| Bio databases IDs | |
| Aliases | vir like m6A methyltransferase associated, functional spliceosome-associated protein 121, virilizer homolog |
| Synonyms | 1110037F02Rik, 4930422M05Rik, fSAP121, KIAA1429, mKIAA1429, MSTP054, RGD1559904, Virilizer, vir like m6A methyltransferase associated |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human VIRMA often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Virilizer, N-terminal
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- melanoma cancer
- colorectal cancer
- breast cancer
- neoplasia
- prostate cancer
- lung cancer
- epithelial cancer
- epithelial neoplasia
- lymphatic neoplasia
- liver cancer
role in cell
- growth
- expression in
- quantity
- proliferation
- cell death
- apoptosis
- phosphorylation in
- migration
- ferroptosis
- G2/M phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- spliceosomes
- nucleoplasm
- nuclear bodies
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human VIRMA gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing
- mRNA processing
- mRNA modification
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- nuclear speck
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding