Lyz2 Gene Summary [Rat]
Enables lysozyme activity. Involved in defense response to Gram-negative bacterium and defense response to Gram-positive bacterium. Located in several cellular components, including Golgi cis cisterna; cytoplasmic vesicle; and rough endoplasmic reticulum lumen. Orthologous to human LYZ (lysozyme). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lyz2 |
| Official Name | lysozyme 2 [Source:RGD Symbol;Acc:3026] |
| Ensembl ID | ENSRNOG00000005825 |
| Bio databases IDs | |
| Aliases | lysozyme 2 |
| Synonyms | Lys, Lysm, lysozyme 1, lysozyme 2, Lysozyme M, Lysozyme p, Lysz, Lyz, Lyz1, Lyz2, Lyzf2, Lyzf3, Lyzs, Lzm, Lzm-s1, Lzp, Lzp-s |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Lyz2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lysozyme
- glycosylase
- enzyme
- lysozyme-like domains
- identical protein binding
Pathways
Biological processes and signaling networks where the Lyz2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- esophageal adenocarcinoma
- multiple system atrophy
- Barrett syndrome
- amyloidosis
- esophageal carcinoma formation
- tauopathy
- dextran sodium sulfate-induced colitis
- proximal tubular toxicity
- insulin-dependent diabetes mellitus
- cerebral hemorrhage
regulates
- IL1B
- Ca2+
- Lyz1/Lyz2
- IL12 (family)
- proteoglycan
role in cell
- expression in
- cell death
- killing
- growth
- survival
- cell viability
- inactivation
- degradation
- dissemination
- growth in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell surface
- Extracellular Space
- cellular membrane
- endosomes
- lysosome
- Golgi Apparatus
- endoplasmic reticulum lumen
- Golgi stacks
- azurophil granules
- rough endoplasmatic reticulum
- specific granules
- secretory granules
- Golgi cisternae
- microvilli
- phagosomes