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LXR/RXR Activation

The retinoid X receptors (RXRs) are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. RXRα is the dimerization partner for the type II nuclear receptors that includes the liver X receptor (LXR). The LXR receptor is activated by oxysterol ligands and forms a heterodimer with RXR. After heterodimerization LXR initiates transcription of target genes by binding to the LXR response element. LXR/RXR is involved in the regulation of lipid metabolism, inflammation, and cholesterol to bile acid catabolism...

LXR/RXR Activation

Pathway Summary

The retinoid X receptors (RXRs) are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. RXRα is the dimerization partner for the type II nuclear receptors that includes the liver X receptor (LXR). The LXR receptor is activated by oxysterol ligands and forms a heterodimer with RXR. After heterodimerization LXR initiates transcription of target genes by binding to the LXR response element. LXR/RXR is involved in the regulation of lipid metabolism, inflammation, and cholesterol to bile acid catabolism. Genes regulated by LXR include the ATP-binding cassette transporter A1 (ABCA1), which effluxes cholesterol from extrahepatic cells, the sterol regulatory element binding protein-1c (SREBP-1c), AIM and LPL.

LXR/RXR Activation Genes list

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GeneGlobe ID: UPHS-056Z | Cat. No.: 249955 | QuantiNova LNA Probe PCR Focus Panels
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GeneGlobe ID: PAHS-180Z | Cat. No.: 330231 | RT2 Profiler PCR Arrays
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GeneGlobe ID: PAHS-056Z | Cat. No.: 330231 | RT2 Profiler PCR Arrays
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