Pla2g5 Gene Summary [Rat]
Enables calcium-dependent phospholipase A2 activity and heparin binding activity. Involved in several processes, including arachidonate secretion; leukotriene biosynthetic process; and platelet activating factor biosynthetic process. Located in perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in familial benign fleck retina. Orthologous to human PLA2G5 (phospholipase A2 group V). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pla2g5 |
| Official Name | phospholipase A2, group V [Source:RGD Symbol;Acc:62051] |
| Ensembl ID | ENSRNOG00000016838 |
| Bio databases IDs | |
| Aliases | phospholipase A2, group V |
| Synonyms | FRFB, GROUP V,PHOSPHOLIPASE A2, GV-PLA2, hVPLA(2), phospholipase A2 group V, phospholipase A2, group V, PLA2-10, sPLA2, sPLA2 V |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pla2g5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- calcium-dependent phospholipase A2
- calcium-independent phospholipase A2
- enzyme
- receptor binding
- heparin binding
- phospholipase A2
- PLA2_like
Pathways
Biological processes and signaling networks where the Pla2g5 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Antioxidant Action of Vitamin C
- Atherosclerosis Signaling
- CCR3 Signaling in Eosinophils
- Docosahexaenoic Acid (DHA) Signaling
- Eicosanoid Signaling
- Endothelin-1 Signaling
- ERK/MAPK Signaling
- Fc Epsilon RI Signaling
- Glucocorticoid Receptor Signaling
- MIF Regulation of Innate Immunity
- MIF-mediated Glucocorticoid Regulation
- Neuroinflammation Signaling Pathway
- p38 MAPK Signaling
- Role of MAPK Signaling in the Pathogenesis of Influenza
- Serotonin Receptor Signaling
- Sperm Motility
- VEGF Family Ligand-Receptor Interactions
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- autosomal dominant late-onset retinal degeneration
- acute myeloid leukemia
- familial benign fleck retina
- acute coronary syndrome
- preeclampsia
- bronchoconstriction
- cardiac fibrosis
role in cell
- apoptosis
- growth
- activation in
- migration
- organismal death
- binding
- production in
- generation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- soluble fraction
- cell surface
- Extracellular Space
- perinuclear region
- Nucleus
- phagolysosome
- cytoplasmic particles
- cytosol
- azurophil granules
- secretory granules
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pla2g5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- low-density lipoprotein particle remodeling
- positive regulation of immune complex clearance by monocytes and macrophages
- phagosome-lysosome fusion
- phospholipid metabolic process
- fatty acid metabolic process
- leukotriene biosynthetic process
- phosphatidylcholine catabolic process
- arachidonic acid secretion
- positive regulation of phospholipase activity
- negative regulation of T cell proliferation
- positive regulation of ERK1 and ERK2 cascade
- cardiolipin acyl-chain remodeling
- positive regulation of macrophage derived foam cell differentiation
- positive regulation of phagocytosis
Cellular Component
Where in the cell the gene product is active
- early phagosome
- phagolysosome
- Golgi apparatus
- recycling endosome
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- calcium-independent phospholipase A2 activity
- calcium-dependent phospholipase A2 activity
- calcium ion binding
- phospholipid binding