Mapk1 Gene Summary [Rat]
Enables several functions, including ATP binding activity; MAP kinase activity; and mitogen-activated protein kinase kinase kinase binding activity. Involved in several processes, including ERK1 and ERK2 cascade; cellular response to cAMP; and positive regulation of macromolecule biosynthetic process. Acts upstream of or within peptidyl-serine phosphorylation. Located in several cellular components, including caveola; dendrite cytoplasm; and perikaryon. Part of protein-containing complex. Is active in postsynaptic density. Used to study several diseases, including alcohol dependence; cocaine abuse; coronary artery disease (multiple); drug dependence (multiple); and gastric ulcer. Biomarker of alcohol use disorder; colon cancer; renal fibrosis; urethral obstruction; and vascular dementia. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome 13; Parkinson's disease; adenocarcinoma (multiple); pulmonary hypertension; and renal cell carcinoma. Orthologous to human MAPK1 (mitogen-activated protein kinase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mapk1 |
| Official Name | mitogen activated protein kinase 1 [Source:RGD Symbol;Acc:70500] |
| Ensembl ID | ENSRNOG00000001849 |
| Bio databases IDs | |
| Aliases | mitogen activated protein kinase 1 |
| Synonyms | 9030612K14Rik, ERK, ERK-2, ERK42, ERT1, Mapk1,2, MAPK2, Mapk p42, mitogen-activated protein kinase 1, MITOGEN ACTIVATED protein KINASE 2, NS13, p38, p40, p40 HERAK, p41, p41mapk, P42, p42 Erk, P42MAPK, PRKM1, PRKM2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mapk1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- activation lip domain
- protein serine/threonine kinase
- protein kinase
- Kinase regulatory loop binding domain
- ATP binding
- common docking domain
- Protein kinase domain
- identical protein binding
- docking domain
- MAP kinase
- alcohol group acceptor phosphotransferase
- MAP kinase site
- phosphatase binding
- insert domain
- [RNA-polymerase]-subunit kinase
- subdomain of kinase domain
- protein kinase binding
- catalytic domain
- phosphotyrosine binding
- dual-specificity motif
- protein binding
- phosphorylation site
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- double-stranded DNA binding
- cytoplasmic localization sequence
- folding domain
Pathways
Biological processes and signaling networks where the Mapk1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Amyloid Processing
- April Mediated Signaling
- Aryl Hydrocarbon Receptor Signaling
- B Cell Activating Factor Signaling
- Cancer Drug Resistance By Drug Efflux
- CNTF Signaling
- CXCR4 Signaling
- Ephrin B Signaling
- ErbB4 Signaling
- GADD45 Signaling
- Glucocorticoid Receptor Signaling
- HER-2 Signaling in Breast Cancer
- HGF Signaling
- IL-17A Signaling in Gastric Cells
- IL-22 Signaling
- JAK/Stat Signaling
- LPS-stimulated MAPK Signaling
- MIF Regulation of Innate Immunity
- Neurotrophin/TRK Signaling
- Oncostatin M Signaling
- Parkinson's Signaling
- Role of IL-17F in Allergic Inflammatory Airway Diseases
- Role of JAK family kinases in IL-6-type Cytokine Signaling
- Role of JAK1 and JAK3 in γc Cytokine Signaling
- Semaphorin Signaling in Neurons
- VEGF Family Ligand-Receptor Interactions
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver neoplasia
- benign neoplasia
- metastasis
- cutaneous melanoma
- BRAF V600 mutation positive cutaneous melanoma
- stage IV cutaneous melanoma
- multisystem Langerhans cell histiocytosis
- Noonan syndrome type 13
- metastatic melanoma
- metastatic cutaneous melanoma
role in cell
- expression in
- invasiveness
- apoptosis
- phosphorylation in
- signaling in
- growth
- downregulation in
- activation in
- survival
- tyrosine phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule fractions
- nuclear fraction
- raft fractions
- caveolae fraction
- soluble fraction
- membrane fraction
- microtubule cytoskeleton
- ficolin-1-rich granule lumen
- azurophil granule lumen
- cytoskeleton
- cilia
- Extracellular Space
- cell periphery
- perinuclear region
- cellular membrane
- focal adhesions
- Nucleus
- Plasma Membrane
- basal bodies
- Golgi Apparatus
- Mitochondria
- midbody
- asters
- cytosol
- endoplasmic reticulum lumen
- apical membrane
- caveolae
- nucleoplasm
- spindle pole
- growth cone
- Z line
- early endosomes
- late endosomes
- pseudopodia
- PML nuclear bodies
- mitotic spindle
- kinetochores
- perikaryon
- axons
- dendrites
- postsynaptic density
- cytoskeletal fraction
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mapk1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to epidermal growth factor stimulus
- trachea formation
- cellular response to amino acid starvation
- face development
- regulation of Golgi inheritance
- learning or memory
- caveolin-mediated endocytosis
- apoptotic process
- long-term synaptic potentiation
- intracellular signal transduction
- stress-activated MAPK cascade
- insulin-like growth factor receptor signaling pathway
- synaptic transmission
- response to DNA damage stimulus
- positive regulation of telomerase activity
- labyrinthine layer blood vessel development
- regulation of cytoskeleton organization
- progesterone receptor signaling pathway
- regulation of stress-activated MAPK cascade
- lipopolysaccharide-mediated signaling pathway
- peptidyl-serine phosphorylation
- cellular response to reactive oxygen species
- peptidyl-threonine phosphorylation
- regulation of early endosome to late endosome transport
- cytosine metabolic process
- Schwann cell development
- insulin receptor signaling pathway
- Bergmann glial cell differentiation
- ERBB2-ERBB3 signaling pathway
- outer ear morphogenesis
- myelination
- protein phosphorylation
- steroid hormone mediated signaling pathway
- lung morphogenesis
- thymus development
- chemotaxis
- negative regulation of cell differentiation
- response to exogenous dsRNA
- positive regulation of macrophage chemotaxis
- cellular response to cadmium ion
- mammary gland epithelial cell proliferation
- cellular response to tumor necrosis factor
- androgen receptor signaling pathway
- regulation of cellular pH
- T cell receptor signaling pathway
- B cell receptor signaling pathway
- ERBB signaling pathway
- signal transduction
- cardiac neural crest cell development involved in heart development
- cell surface receptor signaling pathway
- response to nicotine
- regulation of transcription from RNA polymerase II promoter
- ERK1 and ERK2 cascade
- thyroid gland development
- regulation of protein stability
- positive regulation of telomere maintenance via telomerase
- positive regulation of peptidyl-threonine phosphorylation
- regulation of ossification
Cellular Component
Where in the cell the gene product is active
- late endosome
- Golgi apparatus
- synapse
- extracellular region
- plasma membrane
- nucleoplasm
- endoplasmic reticulum lumen
- nucleus
- caveola
- early endosome
- centrosome
- cytoskeleton
- focal adhesion
- mitotic spindle
- cytoplasm
- mitochondrion
- cytosol
- pseudopodium
- azurophil granule lumen
Molecular Function
What the gene product does at the molecular level
- phosphotyrosine binding
- phosphatase binding
- DNA binding
- ATP binding
- identical protein binding
- protein binding
- RNA polymerase II carboxy-terminal domain kinase activity
- MAP kinase activity
- protein serine/threonine kinase activity