Tgfa Gene Summary [Rat]
Enables epidermal growth factor receptor binding activity. Involved in several processes, including hepatocyte proliferation; negative regulation of apoptotic process; and positive regulation of cell population proliferation. Located in extracellular space. Used to study pancreatic cancer. Biomarker of acute kidney failure and hepatocellular carcinoma. Human ortholog(s) of this gene implicated in gastroenteritis. Orthologous to human TGFA (transforming growth factor alpha). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tgfa |
| Official Name | transforming growth factor alpha [Source:RGD Symbol;Acc:3849] |
| Ensembl ID | ENSRNOG00000016182 |
| Bio databases IDs | |
| Aliases | transforming growth factor alpha |
| Synonyms | ETGF, RATTGFAA, TFGA, TGFAA, Tgf alpha, Tgf α, transforming growth factor alpha, transforming growth factor-α, wa-1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tgfa often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- epidermal growth factor receptor binding
- ectodomain
- protein binding
- prenylation site
- EGF-receptor binding domain
- growth factor
- transmembrane receptor protein tyrosine kinase activator
- cytoplasmic domain
- transmembrane domain
- intracellular domain
- receptor agonist activity
- PDZ binding motif
Pathways
Biological processes and signaling networks where the Tgfa gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Autophagy
- CREB Signaling in Neurons
- Docosahexaenoic Acid (DHA) Signaling
- Ephrin A Signaling
- ErbB Signaling
- Glioma Signaling
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- HER-2 Signaling in Breast Cancer
- HIF1α Signaling
- Neuregulin Signaling
- NF-κB Signaling
- Non-Small Cell Lung Cancer Signaling
- Pancreatic Adenocarcinoma Signaling
- Renal Cell Carcinoma Signaling
- Role of Tissue Factor in Cancer
- STAT3 Pathway
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- primary biliary cirrhosis
- neoplasia
- benign neoplasia
- cancer
- adenoma formation
- epithelial neoplasia
- liver adenoma
- liver neoplasia
- osteoarthritis
- growth failure
role in cell
- transactivation in
- expression in
- phosphorylation in
- cell death
- transcription in
- degradation in
- cell viability
- apoptosis
- differentiation
- invasion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- endocytic vesicle membrane
- Cytoplasm
- cell surface
- cell periphery
- intracellular space
- perinuclear region
- cellular membrane
- Nucleus
- Plasma Membrane
- vesicles
- cell-cell contacts
- apical cell surfaces
- endoplasmic reticulum membrane
- basolateral membrane
- cytoplasmic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tgfa gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ERBB2-EGFR signaling pathway
- epidermal growth factor receptor signaling pathway
- positive regulation of cell proliferation
- cell surface receptor signaling pathway
- positive regulation of mitosis
- positive regulation of MAPK cascade
- positive regulation of cell division
- mammary gland alveolus development
- angiogenesis
- hepatocyte proliferation
- positive regulation of epithelial cell proliferation
- positive regulation of peptidyl-tyrosine phosphorylation
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- extracellular space
- clathrin-coated endocytic vesicle membrane
- perinuclear region of cytoplasm
- ER to Golgi transport vesicle membrane
- cytoplasmic vesicle
- extracellular region
- basolateral plasma membrane
- plasma membrane
- cell surface
- endoplasmic reticulum-Golgi intermediate compartment membrane
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- protein binding
- transmembrane receptor protein tyrosine kinase activator activity
- epidermal growth factor receptor binding
- receptor agonist activity