Ren1 Gene Summary [Mouse]
Enables aspartic-type endopeptidase activity. Involved in angiotensin maturation; male gonad development; and mesonephros development. Acts upstream of or within with a positive effect on regulation of blood pressure. Acts upstream of or within several processes, including drinking behavior; hormone-mediated signaling pathway; and renin-angiotensin regulation of aldosterone production. Located in extracellular space. Is active in extracellular region. Is expressed in several structures, including alimentary system; brain; extraembryonic component; genitourinary system; and trunk. Human ortholog(s) of this gene implicated in autosomal dominant tubulointerstitial kidney disease; essential hypertension; hand, foot and mouth disease; hypertension; and portal hypertension. Orthologous to human REN (renin). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ren1 |
| Official Name | renin 1 structural [Source:MGI Symbol;Acc:MGI:97898] |
| Ensembl ID | ENSMUSG00000070645 |
| Bio databases IDs | |
| Aliases | renin 1 structural |
| Synonyms | Ren, Ren-B, renin 2 tandem duplication of Ren1, Rn-2, Rnr |
| Species | Mouse, Mus musculus |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ren1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Xylanase inhibitor N-terminal
- endopeptidase
- peptidase
- aspartic endopeptidase
- receptor binding
- Cellular and retroviral pepsin-like aspartate proteases
- Eukaryotic aspartyl protease
- insulin-like growth factor receptor binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulated by
- SC-58125
- PTGIR
disease
- hypertension
- juvenile hyaline fibromatosis
- diastolic dysfunction
- reactive hypoglycemia
- perivascular fibrosis
phenotypes
- abnormal baroreceptor physiology
- abnormal blood homeostasis
- abnormal innervation
- abnormal juxtaglomerular apparatus morphology
- abnormal juxtaglomerular cell morphology
- abnormal kidney afferent arteriole morphology
- abnormal kidney cortex morphology
- abnormal kidney interlobular artery morphology
- abnormal kidney medulla morphology
- abnormal locomotor behavior
- abnormal macula densa morphology
- abnormal renal glomerulus morphology
- abnormal urine homeostasis
- decreased body weight
- decreased circulating renin level
- decreased hematocrit
- decreased kidney weight
- decreased mean systemic arterial blood pressure
- decreased physiological sensitivity to xenobiotic
- decreased renal glomerular filtration rate
- decreased systemic arterial blood pressure
- decreased systemic arterial diastolic blood pressure
- decreased systemic arterial systolic blood pressure
- decreased urine osmolality
- decreased vasoconstriction
- dehydration
- dilated renal tubules
- glomerulosclerosis
- granular kidney
- hydronephrosis
- hypotension
- increased blood urea nitrogen level
- increased circulating aldosterone level
- increased circulating creatinine level
- increased circulating potassium level
- increased heart rate
- kidney atrophy
- kidney cortex atrophy
- kidney inflammation
- kidney medulla atrophy
- kidney papillary atrophy
- kidney papillary hypoplasia
- metabolic acidosis
- no abnormal phenotype detected
- polydipsia
- polyuria
- postnatal lethality complete penetrance
- postnatal lethality incomplete penetrance
- proximal convoluted tubule brush border loss
- renal glomerulus atrophy
- renal glomerulus fibrosis
- renal glomerulus hypertrophy
- renal interstitial fibrosis
- renal tubule atrophy
- small kidney
- vascular smooth muscle hyperplasia
role in cell
- damage
- loss
- peroxidation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- apical compartment