TIMM17A Gene Summary

Predicted to contribute to protein transmembrane transporter activity. Predicted to be involved in protein import into mitochondrial matrix. Located in mitochondrial inner membrane and nucleoplasm. Is integral component of mitochondrial inner membrane. Part of TIM23 mitochondrial import inner membrane translocase complex. [provided by Alliance of Genome Resources, Apr 2022]

Details

Type
Protein Coding
Official Symbol
TIMM17A
Official Name
translocase of inner mitochondrial membrane 17A [Source:HGNC Symbol;Acc:HGNC:17315]
Ensembl ID
ENSG00000134375
Bio databases IDs NCBI: 10440 Ensembl: ENSG00000134375
Aliases translocase of inner mitochondrial membrane 17A
Synonyms
Mitochondrial import inner membrane translocase,Mitochondrial protein import protein 2,mTim17a,TIM17,TIM17A,Timm17,translocase of inner mitochondrial membrane 17A
Species
Human, Homo sapiens

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • TIM22
  • enzyme binding
  • protein binding
  • Tim17/Tim22/Tim23/Pmp24 family
  • transporter

Pathways

Biological processes and signaling networks where the TIMM17A gene plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulated by
  • D-glucose
  • NLRX1
  • ELAVL1
  • OGT
  • PDGF-BB
  • glutamine
  • pirinixic acid
  • fenofibrate
  • doxorubicin
  • hydrogen peroxide

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • Mitochondria
  • mitochondrial inner membrane
  • nucleoplasm

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the TIMM17A gene, providing context for its role in the cell.

biological PROCESS

Functions and activities the gene product is involved in
  • protein targeting to mitochondrion
  • protein import into mitochondrial matrix
  • intracellular protein transport

cellular COMPONENT

Where in the cell the gene product is active
  • mitochondrial inner membrane presequence translocase complex
  • mitochondrion
  • mitochondrial inner membrane
  • nucleoplasm

molecular FUNCTION

What the gene product does at the molecular level
  • protein transmembrane transporter activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.