DNAJC15 Gene Summary [Human]
Predicted to enable ATPase activator activity. Predicted to be involved in protein import into mitochondrial matrix. Predicted to act upstream of or within several processes, including cellular response to starvation; negative regulation of mitochondrial electron transport, NADH to ubiquinone; and negative regulation of protein-containing complex assembly. Predicted to be located in mitochondrial inner membrane. Predicted to be part of PAM complex, Tim23 associated import motor. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Processed Transcript |
| Official Symbol | DNAJC15 |
| Official Name | DnaJ heat shock protein family (Hsp40) member C15 [Source:HGNC Symbol;Acc:HGNC:20325] |
| Ensembl ID | ENSG00000120675 |
| Bio databases IDs | |
| Aliases | DnaJ heat shock protein family (Hsp40) member C15 |
| Synonyms | 1110003P16Rik, DNAJD1, DnaJ heat shock protein family (Hsp40) member C15, HSD18, MCJ |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DNAJC15 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DnaJ domain
- DnaJ
- DnaJ molecular chaperone homology domain
- protein binding
Pathways
Biological processes and signaling networks where the DNAJC15 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi Apparatus
- Mitochondria
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DNAJC15 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein import into mitochondrial matrix
- macromolecular complex assembly
- mitochondrial electron transport, NADH to ubiquinone
- negative regulation of protein complex assembly
- cellular response to starvation
- intracellular protein transport
- regulation of lipid metabolic process
Cellular Component
Where in the cell the gene product is active
- mitochondrial inner membrane presequence translocase complex
- presequence translocase-associated import motor
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- ATPase activator activity