OGT Gene Summary [Human]
This gene encodes a glycosyltransferase that catalyzes the addition of a single N-acetylglucosamine in O-glycosidic linkage to serine or threonine residues. Since both phosphorylation and glycosylation compete for similar serine or threonine residues, the two processes may compete for sites, or they may alter the substrate specificity of nearby sites by steric or electrostatic effects. The protein contains multiple tetratricopeptide repeats that are required for optimal recognition of substrates. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Details
| Type | Retained Intron |
| Official Symbol | OGT |
| Official Name | O-linked N-acetylglucosamine (GlcNAc) transferase [Source:HGNC Symbol;Acc:HGNC:8127] |
| Ensembl ID | ENSG00000147162 |
| Bio databases IDs | |
| Aliases | O-linked N-acetylglucosamine (GlcNAc) transferase, UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase |
| Synonyms | 1110038P24Rik, 4831420N21Rik, HINCUT-1, HRNT1, MRX106, O-GLCNAC, OGT1, Ogtl, O-linked N-acetylglucosamine (GlcNAc) transferase, O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase), XLID106 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human OGT often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Bacterial transcriptional activator domain
- glycosyltransferase family 1 and related proteins with GTB topology
- MalT-like TPR region
- peptide binding
- TPR repeat
- Soluble N-ethylmaleimide-sensitive factor (NSF) Attachment Protein family
- catalytic domain
- acetylglucosaminyltransferase
- protein domain specific binding
- chromatin binding
- enzyme
- protein binding
- identical protein binding
- DNA binding
- N-acetyltransferase
- binding protein
- Glycosyl transferase family 41
- Tetratricopeptide Repeats-Sensor
- phosphatidylinositol-3,4,5-triphosphate binding
- Tetratricopeptide repeats
- type IV pilus biogenesis/stability protein PilW
- tetratricopeptide repeat
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- pulmonary fibrosis
- non-insulin-dependent diabetes mellitus
- hypertension
- Alzheimer disease
- hepatic fibrosis
- adenoma formation
- liver cancer
- X-linked mental retardation type 106
- obesity
role in cell
- loss
- expression in
- accumulation in
- phosphorylation in
- activation in
- migration
- invasion by
- proliferation
- morphology
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- interchromatin granule cluster fractions
- glutaminergic synapse
- intracellular space
- inner membrane
- ribosome
- Nucleus
- Plasma Membrane
- Mitochondria
- cytosol
- nucleoplasm
- zymogen granules
- synapse
- membrane rafts
- chromatin
- perikaryon
- excitatory synapses
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human OGT gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of translation
- regulation of Rac protein signal transduction
- hemopoiesis
- positive regulation of proteolysis
- chromatin organization
- positive regulation of transcription from RNA polymerase II promoter
- regulation of necroptosis
- positive regulation of transcription from RNA polymerase II promoter by glucose
- negative regulation of transcription from RNA polymerase II promoter
- circadian regulation of gene expression
- response to insulin stimulus
- cellular response to glucose stimulus
- positive regulation of transcription, DNA-dependent
- apoptotic process
- negative regulation of protein ubiquitination
- regulation of synapse assembly
- protein O-linked glycosylation
- signal transduction
- response to nutrient
- regulation of glycolysis
- regulation of gluconeogenesis
- macromitophagy
- regulation of insulin receptor signaling pathway
- regulation of transcription from RNA polymerase II promoter
- positive regulation of lipid biosynthetic process
- protein processing
- negative regulation of transforming growth factor beta receptor signaling pathway
- negative regulation of cell migration
- negative regulation of proteasomal ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrial membrane
- protein N-acetylglucosaminyltransferase complex
- cytosol
- macromolecular complex
- NSL complex
- cell projection
- plasma membrane
- Sin3-type complex
- nucleoplasm
- histone acetyltransferase complex
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol-3,4,5-trisphosphate binding
- chromatin DNA binding
- protein binding
- acetylglucosaminyltransferase activity