CLEC16A Gene Summary [Human]
This gene encodes a member of the C-type lectin domain containing family. Single nucleotide polymorphisms in introns of this gene have been associated with diabetes mellitus, multiple sclerosis and rheumatoid arthritis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Details
| Type | Protein Coding |
| Official Symbol | CLEC16A |
| Official Name | C-type lectin domain containing 16A [Source:HGNC Symbol;Acc:HGNC:29013] |
| Ensembl ID | ENSG00000038532 |
| Bio databases IDs | |
| Aliases | C-type lectin domain containing 16A |
| Synonyms | 4932416N17Rik, CL16A, C-type lectin domain containing 16A, C-type lectin domain family 16, member A, curt, Gop-1, KIAA0350, mKIAA0350, RGD1305773, Riken cDNA 4932416n17 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CLEC16A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CLEC16A C-terminal
- Uncharacterized conserved protein
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- head and neck neoplasia
- non-insulin-dependent diabetes mellitus
- chronic sinusitis
- multiple sclerosis
- allergic rhinitis
- systemic lupus erythematosus
- asthma
- microscopic colitis
- IgA deficiency
- uterine leiomyoma
regulates
- proinsulin
- PRKN
- proteasome
- Shiga toxin 2
- oxygen
role in cell
- expression in
- quantity
- response
- maturation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- vesicles
- Golgi Apparatus
- cytosol
- lysosome membrane
- endosomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CLEC16A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- autophagy
- endosomal transport
- endosome to lysosome transport
- cellular response to starvation
Cellular Component
Where in the cell the gene product is active
- endolysosome membrane
- late endosome
- vesicle
- cytosol
- Golgi apparatus