PNOC Gene Summary
This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include nociceptin, nocistatin, and orphanin FQ2 (OFQ2). Nociceptin, also known as orphanin FQ, is a 17-amino acid neuropeptide that binds to the nociceptin receptor to induce increased pain sensitivity, and may additionally regulate body temperature, learning and memory, and hunger. Another product of the encoded preproprotein, nocistatin, may inhibit the effects of nociceptin. [provided by RefSeq, Jul 2015]
Details
| Type | Protein Coding |
| Official Symbol | PNOC |
| Official Name | prepronociceptin [Source:HGNC Symbol;Acc:HGNC:9163] |
| Ensembl ID | ENSG00000168081 |
| Bio databases IDs | |
| Aliases | prepronociceptin, nocistatin, orphanin FQ |
| Synonyms | N23K,Neuropeptide nociceptin 1,Nociceptine,N/OFQ,NOP,Npnc1,OFQ,OFQ/N,PPNOC,ppN/OFQ,prepronociceptin |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Vertebrate endogenous opioids neuropeptide
- receptor agonist activity
- protein binding
- neuropeptide hormone
Pathways
Biological processes and signaling networks where the PNOC gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metabolic syndrome X
- diabetic nephropathy
- hypotension
- allodynia
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
- lung adenocarcinoma
- lung adenocarcinoma formation
- pain
- hyperalgesia
role in cell
- activation in
- chemotaxis
- binding in
- accumulation in
- binding
- inhibitory postsynaptic potential
- inhibition in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- membrane fraction
- cellular membrane
- Plasma Membrane
- synaptic membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the PNOC gene, providing context for its role in the cell.
biological PROCESS
Functions and activities the gene product is involved in
- neuron-neuron synaptic transmission
- neuropeptide signaling pathway
- signal transduction
- synaptic transmission
- female pregnancy
- sensory perception of pain
- sensory perception
cellular COMPONENT
Where in the cell the gene product is active
- dendrite
- neuronal cell body
- synaptic membrane
- extracellular region
- plasma membrane
- axon terminus
molecular FUNCTION
What the gene product does at the molecular level
- opioid peptide activity
- opioid receptor binding
- neuropeptide hormone activity