FBXO7 Gene Summary [Human]
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it may play a role in regulation of hematopoiesis. Alternatively spliced transcript variants of this gene have been identified with the full-length natures of only some variants being determined. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | FBXO7 |
| Official Name | F-box protein 7 [Source:HGNC Symbol;Acc:HGNC:13586] |
| Ensembl ID | ENSG00000100225 |
| Bio databases IDs | |
| Aliases | F-box protein 7 |
| Synonyms | 2410015K21RIK, A230052G17RIK, AI117679, AW260462, F-box protein 7, FBX, FBX07, FBX7, PARK15, PKPS |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FBXO7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- protein kinase binding
- nuclear export signal
- F-box domain superfamily
- protein binding activity, bridging
- ubiquitin binding
- enzyme
- protein binding
- ubiquitin-like domain
- proline rich domain
- PI31 proteasome regulator N-terminal
- F-box domain
- Ubl1_cv_Nsp3_N-like
- ubiquitin-protein transferase activity
- F-box-like
- protein heterodimerization
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- Parkinson disease 15
- organismal death
- endometrial carcinoma
- epithelial endometrial cancer
- motor dysfunction
- ovarian cancer
- renal cell carcinoma
- renal cell cancer
role in cell
- proliferation
- apoptosis
- expression in
- acetylation in
- migration
- invasion by
- accumulation in
- differentiation
- cell death
- transformation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular space
- Nucleus
- Mitochondria
- cytosol
- nucleoplasm
- neurites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FBXO7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein K48-linked ubiquitination
- regulation of locomotion
- negative regulation of lymphocyte differentiation
- mitochondrion degradation
- ubiquitin-dependent protein catabolic process
- protein targeting to mitochondrion
- proteasomal ubiquitin-dependent protein catabolic process
- regulation of protein stability
- negative regulation of G1/S transition of mitotic cell cycle
- lymphocyte differentiation
- regulation of neuron projection development
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- ubiquitin ligase complex
- cytoplasm
- mitochondrion
- cytosol
- SCF ubiquitin ligase complex
- macromolecular complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- protein kinase binding
- ubiquitin protein ligase binding
- protein binding
- ubiquitin binding
- protein heterodimerization activity