THOP1 Gene Summary [Human]
The protein encoded by this gene is a kininase that uses zinc as a cofactor. The encoded oligopeptidase cleaves cytosolic peptides, making them unavailable for display on antigen-presenting cells. This protein also cleaves neuropeptides under 20 aa in length and can degrade beta-amyloid precursor protein to amyloidogenic peptides. [provided by RefSeq, Nov 2015]
Details
| Type | Protein Coding |
| Official Symbol | THOP1 |
| Official Name | thimet oligopeptidase 1 [Source:HGNC Symbol;Acc:HGNC:11793] |
| Ensembl ID | ENSG00000172009 |
| Bio databases IDs | |
| Aliases | thimet oligopeptidase 1 |
| Synonyms | EP24.15, Metalloendopeptidase, MP78, PZ-PEPTIDASE, THIMET OLIGOPEPTIDASE, thimet oligopeptidase 1, TOP |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human THOP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- peptide binding
- thimet oligopeptidase
- peptidase
- protein binding
- Peptidase family M3
- peptidase GluZincin family
- metalloendopeptidase
Pathways
Biological processes and signaling networks where the THOP1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lymphoma
- diabetes mellitus
- lymphomagenesis
- hepatitis
- schizophrenia
- chronic hepatitis
- alcoholic hepatitis
role in cell
- signal transduction in
- generation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human THOP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- peptide metabolic process
- protein polyubiquitination
- proteolysis
Cellular Component
Where in the cell the gene product is active
- mitochondrial intermembrane space
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- metalloendopeptidase activity