SND1 Gene Summary [Human]
This gene encodes a transcriptional co-activator that interacts with the acidic domain of Epstein-Barr virus nuclear antigen 2 (EBNA 2), a transcriptional activator that is required for B-lymphocyte transformation. Other transcription factors that interact with this protein are signal transducers and activators of transcription, STATs. This protein is also thought to be essential for normal cell growth. A similar protein in mammals and other organisms is a component of the RNA-induced silencing complex (RISC). [provided by RefSeq, Jul 2016]
Details
| Type | Protein Coding |
| Official Symbol | SND1 |
| Official Name | staphylococcal nuclease and tudor domain containing 1 [Source:HGNC Symbol;Acc:HGNC:30646] |
| Ensembl ID | ENSG00000197157 |
| Bio databases IDs | |
| Aliases | staphylococcal nuclease and tudor domain containing 1, p100 EBNA2 co-activator, Tudor-SN |
| Synonyms | Loc56463, p100, P100-coactivator, SND p102, staphylococcal nuclease and tudor domain containing 1, TDRD11, TSN, Tudor-SN, U83883 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SND1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- Tudor domain
- transcription co-activator
- Staphylococcal nuclease homologues
- transcription cofactor
- protein binding
- MYB binding EVES domain
- RNA binding
- endonuclease
- ribonucleoprotein binding
- endoribonuclease
- SNc
- Tudor domain superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- prostate cancer
- schizophrenia
- organismal death
- peptic ulcer disease
- lung metastasis
- non-insulin-dependent diabetes mellitus
- hemorrhoid
- pervasive developmental disorder
- rheumatoid arthritis
- insomnia
role in cell
- apoptosis
- growth
- activation in
- proliferation
- upregulation in
- expression in
- downregulation in
- recruitment in
- cell viability
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- detergent resistant lipid raft fraction
- Cytoplasm
- punctate structures
- Endoplasmic Reticulum
- granules
- cytosol
- extranucleolar nucleoplasm
- perikaryon
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SND1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- osteoblast differentiation
- gene silencing by RNA
- mRNA catabolic process
- miRNA catabolic process
- regulation of cell cycle process
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- melanosome
- membrane
- RNAi effector complex
- cytosol
Molecular Function
What the gene product does at the molecular level
- transcription cofactor activity
- RNA binding
- protein binding
- cadherin binding
- endonuclease activity
- nuclease activity
- endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters
- endoribonuclease activity