DDX60 Gene Summary [Human]
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases which are implicated in a number of cellular procsses involving RNA binding and alteration of RNA secondary structure. This gene encodes a DEXD/H box RNA helicase that functions as an antiviral factor and promotes RIG-I-like receptor-mediated signaling. [provided by RefSeq, Apr 2017]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | DDX60 |
| Official Name | DExD/H-box helicase 60 [Source:HGNC Symbol;Acc:HGNC:25942] |
| Ensembl ID | ENSG00000137628 |
| Bio databases IDs | |
| Aliases | DExD/H-box helicase 60 |
| Synonyms | DExD/H-box helicase 60, FLJ20035 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DDX60 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- double-stranded DNA binding
- helicase superfamily c-terminal domain
- double-stranded RNA binding
- DEAD/DEAH box helicase
- Type III restriction enzyme, res subunit
- N-terminal helicase domain of the DEAD-box helicase superfamily
- enzyme
- protein binding
- DEAD-like helicases superfamily
- single-stranded RNA binding
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- systemic lupus erythematosus
- hyperzincemia and hypercalprotectinemia autoinflammatory syndrome
- complete testicular feminization syndrome
- diabetes mellitus
- gastric epithelial cancer
- gastric adenocarcinoma
- ATAD3A-related type I interferonopathy
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intermediate filament cytoskeleton
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DDX60 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- innate immune response
- positive regulation of MDA-5 signaling pathway
- defense response to virus
- positive regulation of RIG-I signaling pathway
- response to virus
Cellular Component
Where in the cell the gene product is active
- intermediate filament cytoskeleton
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- protein binding
- RNA helicase activity
- double-stranded RNA binding
- single-stranded RNA binding
- double-stranded DNA binding