ZNF598 Gene Summary [Human]
Zinc-finger proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation, and apoptosis. This protein and Grb10-interacting GYF protein 2 have been identified as a components of the mammalian 4EHP (m4EHP) complex. The complex is thought to function as a translation repressor in embryonic development. [provided by RefSeq, Oct 2012]
Details
| Type | Retained Intron |
| Official Symbol | ZNF598 |
| Official Name | zinc finger protein 598, E3 ubiquitin ligase [Source:HGNC Symbol;Acc:HGNC:28079] |
| Ensembl ID | ENSG00000167962 |
| Bio databases IDs | |
| Aliases | zinc finger protein 598, E3 ubiquitin ligase |
| Synonyms | HEL2, Ntrap, Zfp598, zinc finger protein 598, zinc finger protein 598, E3 ubiquitin ligase |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ZNF598 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase activity
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- protein binding activity, bridging
- ribosome binding
- enzyme
- protein binding
- enzyme regulator activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- ribosome
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ZNF598 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of translational initiation
- rescue of stalled ribosome
- protein K63-linked ubiquitination
- protein monoubiquitination
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- cytosolic ribosome
- cytosol
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- metal ion binding
- ribosome binding