EIF5B
EIF5B Gene Summary
Accurate initiation of translation in eukaryotes is complex and requires many factors, some of which are composed of multiple subunits. The process is simpler in prokaryotes which have only three initiation factors (IF1, IF2, IF3). Two of these factors are conserved in eukaryotes: the homolog of IF1 is eIF1A and the homolog of IF2 is eIF5B. This gene encodes eIF5B. Factors eIF1A and eIF5B interact on the ribosome along with other initiation factors and GTP to position the initiation methionine tRNA on the start codon of the mRNA so that translation initiates accurately. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | EIF5B |
| Official Name | eukaryotic translation initiation factor 5B [Source:HGNC Symbol;Acc:HGNC:30793] |
| Ensembl ID | ENSG00000158417 |
| Bio databases IDs | |
| Aliases | eukaryotic translation initiation factor 5B, translation initiation factor IF2 |
| Synonyms | A030003E17Rik,BC018347,eukaryotic translation initiation factor 5B,IF2,Initiation Factor M2,LOC308306 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- tRNA binding
- translation initiation factor IF-2
- Elongation factor Tu domain 4
- translation initiation factor aIF-2/yIF-2
- GTPase
- protein binding
- Elongation factor Tu domain 2
- translation regulator
- GTP binding
- Domain II of Elongation factor Tu (EF-Tu)-like proteins
- PRK04004
- small GTP-binding protein domain
- translation initiation factor
- Elongation factor Tu GTP binding domain
- Ras of Complex, Roc, domain of DAPkinase
- Translation-initiation factor 2
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the EIF5B gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- KIF14
- SNCA
- ESR1
- CEBPB
- SMC5
- PHLPP1
- TRIM67
- BRCA1
- RWDD1
- HSPA1A
disease
- hepatocellular carcinoma
- epithelial cancer
- liver cancer
- androgenic alopecia
regulated by
- PGR
- WNT1
- tretinoin
- natural T-regulatory cells
- GABA
- progesterone
- CSNK2A1
- AGRN
- RYR1
- CST5
regulates
- RELA
- NFkB (complex)
- SOX2
- NFKBIA
- VIM
- CDH1
- MMP9
- XIAP
- CDH2
- ALDH1A1
role in cell
- phosphorylation in
- proliferation
- expression in
- activation in
- sphere formation
- invasion by
- morphology
- assembly
- necroptosis
- synthesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the EIF5B gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- ribosome assembly
- regulation of translational initiation
- translational initiation
CELLULAR COMPONENT
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- synapse
MOLECULAR FUNCTION
What the gene product does at the molecular level
- GTP binding
- translation initiation factor activity
- RNA binding
- protein binding
- metal ion binding
- GTPase activity
- tRNA binding