IRGM Gene Summary [Human]
This gene encodes a member of the p47 immunity-related GTPase family. The encoded protein may play a role in the innate immune response by regulating autophagy formation in response to intracellular pathogens. Polymorphisms that affect the normal expression of this gene are associated with a susceptibility to Crohn's disease and tuberculosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2016]
Details
| Type | Protein Coding |
| Official Symbol | IRGM |
| Official Name | immunity related GTPase M [Source:HGNC Symbol;Acc:HGNC:29597] |
| Ensembl ID | ENSG00000237693 |
| Bio databases IDs | |
| Aliases | immunity related GTPase M |
| Synonyms | IBD19, IFI1, Immunity related GTPase M, IRGM1, LRG-47 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IRGM often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CARD domain binding
- protein kinase activator
- phospholipid binding
- binding protein
- protein kinase binding
- small monomeric GTPase
- protein binding activity, bridging
- GTPase
- protein domain specific binding
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- ulcerative colitis
- multiple sclerosis
- inflammatory bowel disease
- Crohn disease
- inflammatory bowel disease type 19
role in cell
- phosphorylation in
- expression in
- apoptosis
- upregulation in
- autophagy by
- cell death
- production in
- polarization
- maturation
- response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- autophagosomal membrane
- Golgi Apparatus
- Mitochondria
- cytosol
- Golgi membrane
- mitochondrial membrane
- mitochondrial inner membrane
- lysosome membrane
- autophagic vacuoles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IRGM gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of I-kappaB kinase/NF-kappaB cascade
- autophagic vacuole assembly
- inflammatory response
- protein targeting to vacuole involved in autophagy
- positive regulation of macrophage activation
- negative regulation of interferon-gamma production
- cellular response to interferon-beta
- positive regulation of peptidyl-serine phosphorylation
- negative regulation of type I interferon production
- macromolecular complex assembly
- defense response to Gram-negative bacterium
- negative regulation of inflammatory response
- regulation of protein complex assembly
- defense response to bacterium
- positive regulation of interferon-gamma-mediated signaling pathway
- negative regulation of NLRP3 inflammasome complex assembly
- protein destabilization
- positive regulation of autophagy
- cellular response to lipopolysaccharide
- nucleotide-binding oligomerization domain containing 2 signaling pathway
- innate immune response
- positive regulation of protein phosphorylation
- positive regulation of peptidyl-threonine phosphorylation
- protein stabilization
- positive regulation of protein serine/threonine kinase activity
- negative regulation of defense response to virus
Cellular Component
Where in the cell the gene product is active
- Golgi apparatus
- Golgi membrane
- cell projection
- phagocytic cup
- lysosomal membrane
- autophagic vacuole membrane
- endoplasmic reticulum membrane
- late endosome membrane
- mitochondrial membrane
- mitochondrion
- phagocytic vesicle membrane
- cytosol
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein kinase binding
- BH3 domain binding
- protein serine/threonine kinase activator activity
- protein binding
- GTPase activity
- small monomeric GTPase activity
- CARD domain binding
- protein binding, bridging