NONO Gene Summary [Human]
This gene encodes an RNA-binding protein which plays various roles in the nucleus, including transcriptional regulation and RNA splicing. A rearrangement between this gene and the transcription factor E3 gene has been observed in papillary renal cell carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes exist on Chromosomes 2 and 16. [provided by RefSeq, Feb 2009]
Details
| Type | Protein Coding |
| Official Symbol | NONO |
| Official Name | non-POU domain containing octamer binding [Source:HGNC Symbol;Acc:HGNC:7871] |
| Ensembl ID | ENSG00000147140 |
| Bio databases IDs | |
| Aliases | non-POU domain containing octamer binding, Nuclear RNA-binding protein, 54-kD, non-Pou domain-containing octamer (ATGCAAAT) binding protein, protein phosphatase 1, regulatory subunit 114 |
| Synonyms | MRXS34, NMT55, nonA, non-POU domain containing octamer binding, non-POU domain containing, octamer-binding, non-POU-domain-containing, octamer binding protein, NRB54, Nuclear RNA-binding protein, 54-kD, P54, P54NRB, PPP1R114 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NONO often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- transcription regulator
- eNOPS_SF
- NOPS (NUC059) domain
- RNA recognition motif
- chromatin binding
- protein binding
- identical protein binding
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rheumatoid arthritis
- epithelial cancer
- neoplasia
- liver cancer
- syndromic X-linked mental retardation type 34
- hepatocellular carcinoma
- brain cancer
- organismal death
- breast cancer
- rectum cancer
role in cell
- expression in
- proliferation
- apoptosis
- phosphorylation in
- accumulation in
- growth
- quantity
- synthesis in
- binding in
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- fibrillar center
- Cytoplasm
- nucleoplasm
- nucleoli
- nuclear bodies
- interchromatin granule clusters
- nuclear envelope
- nuclear speckles
- nuclear matrix
- chromatin
- paraspeckle-like structures
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NONO gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- RNA splicing
- negative regulation of transcription, DNA-dependent
- activation of innate immune response
- innate immune response
- DNA recombination
- regulation of transcription, DNA-dependent
- mRNA processing
- regulation of circadian rhythm
- circadian rhythm
Cellular Component
Where in the cell the gene product is active
- nucleus
- paraspeckles
- nuclear speck
- membrane
- nuclear matrix
- chromosome
- fibrillar center
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- identical protein binding
- protein binding
- RNA binding
- chromatin binding