USP22 Gene Summary [Human]
Enables enzyme binding activity; nuclear receptor coactivator activity; and thiol-dependent deubiquitinase. Contributes to H4 histone acetyltransferase activity. Involved in positive regulation of mitotic cell cycle; positive regulation of transcription, DNA-templated; and protein modification by small protein conjugation or removal. Part of SAGA complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | USP22 |
| Official Name | ubiquitin specific peptidase 22 [Source:HGNC Symbol;Acc:HGNC:12621] |
| Ensembl ID | ENSG00000124422 |
| Bio databases IDs | |
| Aliases | ubiquitin specific peptidase 22 |
| Synonyms | ubiquitin specific peptidase 22, USP3L |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human USP22 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone acetyltransferase
- transcription co-activator
- coiled-coil like domain
- peptidase
- nuclear localization sequence
- enzyme binding
- enzyme
- protein binding
- Hdac domain
- Peptidase_C19
- ubiquitin thiolesterase
- Zn-finger in ubiquitin-hydrolases and other protein
- C19 ubiquitin-specific peptidase domain
- Ubiquitin carboxyl-terminal hydrolase
- ubiquitin-specific protease
- zinc finger domain
- ubiquitin-like-specific protease
Pathways
Biological processes and signaling networks where the USP22 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- tumorigenesis
- COVID-19
- organismal death
- growth failure
- infection by severe acute respiratory syndrome coronavirus 2
role in cell
- accumulation in
- apoptosis
- phosphorylation in
- expression in
- binding in
- number
- survival
- migration
- proliferation
- replication in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human USP22 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein deubiquitination
- chromatin remodeling
- G2/M transition of mitotic cell cycle
- positive regulation of transcription, DNA-dependent
- embryo development ending in birth or egg hatching
- regulation of RNA splicing
- positive regulation of type I interferon production
- regulation of DNA repair
- proteolysis
- positive regulation of mitotic cell cycle
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor TFTC complex
- cytoplasm
- SAGA complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-specific protease activity
- zinc ion binding
- protein binding
- transcription coactivator activity
- ligand-dependent nuclear receptor transcription coactivator activity
- H4 histone acetyltransferase activity
- enzyme binding