CRHBP Gene Summary [Human]
Corticotropin-releasing hormone is a potent stimulator of synthesis and secretion of preopiomelanocortin-derived peptides. Although CRH concentrations in the human peripheral circulation are normally low, they increase throughout pregnancy and fall rapidly after parturition. Maternal plasma CRH probably originates from the placenta. Human plasma contains a CRH-binding protein which inactivates CRH and which may prevent inappropriate pituitary-adrenal stimulation in pregnancy. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | CRHBP |
| Official Name | corticotropin releasing hormone binding protein [Source:HGNC Symbol;Acc:HGNC:2356] |
| Ensembl ID | ENSG00000145708 |
| Bio databases IDs | |
| Aliases | corticotropin releasing hormone binding protein |
| Synonyms | corticotropin releasing hormone binding protein, CRF-BP |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CRHBP often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Corticotropin-releasing factor binding protein (CRF-BP)
- peptide binding
- protein binding
- polypeptide hormone binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- bipolar disorder
- schizophrenia
- epithelial cancer
- hepatocellular carcinoma
- liver cancer
- diabetic nephropathy
- growth failure
- acne
role in cell
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- axon component
- Cytoplasm
- Nucleus
- lysosome
- microtubules
- multivesicular bodies
- secretory granules
- perikaryon
- dendrites
- axon terminals
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CRHBP gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- negative regulation of corticotropin-releasing hormone receptor activity
- female pregnancy
- regulation of cellular response to stress
- behavioral response to ethanol
- cellular response to estrogen stimulus
- learning or memory
- hormone-mediated signaling pathway
- cellular response to estradiol stimulus
- inflammatory response
- synaptic transmission, dopaminergic
- cellular response to gonadotropin-releasing hormone
- cellular response to calcium ion
- negative regulation of corticotropin secretion
- regulated secretory pathway
- cellular response to cAMP
- cellular response to cocaine
- regulation of N-methyl-D-aspartate selective glutamate receptor activity
- cellular response to tumor necrosis factor
- cellular response to xenobiotic stimulus
- regulation of corticotropin secretion
- cellular response to potassium ion
Cellular Component
Where in the cell the gene product is active
- secretory granule
- Golgi apparatus
- endoplasmic reticulum
- multivesicular body
- extracellular region
- perikaryon
- axon terminus
- microtubule
- secondary lysosome
- nucleus
- dendrite
- extracellular space
- varicosity
- dense core granule
Molecular Function
What the gene product does at the molecular level
- protein binding
- peptide binding
- corticotropin-releasing hormone binding