SPRR1A Gene Summary [Human]
A structural constituent of skin epidermis. Involved in keratinocyte differentiation and peptide cross-linking. Located in cornified envelope. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | SPRR1A |
| Official Name | small proline rich protein 1A [Source:HGNC Symbol;Acc:HGNC:11259] |
| Ensembl ID | ENSG00000169474 |
| Bio databases IDs | |
| Aliases | small proline rich protein 1A, cornifin-A |
| Synonyms | small proline rich protein 1A, SPR-IA, SPRK |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SPRR1A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- structural constituent of epidermis
- protein binding
- structural molecule
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- plaque psoriasis
- non-small cell lung cancer
- psoriasis
- chronic periodontal disease
- idiopathic pulmonary fibrosis
regulates
- peptide
role in cell
- differentiation
- outgrowth
- crizotinib sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cornified envelope
- cytosol
- membrane ruffles
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SPRR1A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- keratinocyte differentiation
- epidermis development
- keratinization
- peptide cross-linking
Cellular Component
Where in the cell the gene product is active
- cornified envelope
- cytosol
Molecular Function
What the gene product does at the molecular level
- structural constituent of epidermis
- protein binding
- structural molecule activity