IL1A Gene Summary [Human]
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | IL1A |
| Official Name | interleukin 1 alpha [Source:HGNC Symbol;Acc:HGNC:5991] |
| Ensembl ID | ENSG00000115008 |
| Bio databases IDs | |
| Aliases | interleukin 1 alpha, preinterleukin 1 alpha, hematopoietin-1, pro-interleukin-1-alpha |
| Synonyms | IL1, IL1-ALPHA, IL-1F1, IL-1 α, interleukin 1 alpha, interleukin-1 α, Interleukin-A |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IL1A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- copper ion binding
- Interleukin-1 propeptide
- propiece
- protein binding
- cytokine
- pro domain
- beta-trefoil domain found in the interleukin-1 (IL-1) family of cytokines
Pathways
Biological processes and signaling networks where the IL1A gene in human plays a role, providing insight into its function and relevance in health or disease.
- Acute Phase Response Signaling
- Aryl Hydrocarbon Receptor Signaling
- Atherosclerosis Signaling
- Cholecystokinin/Gastrin-mediated Signaling
- Communication between Innate and Adaptive Immune Cells
- Dendritic Cell Maturation
- Differential Regulation of Cytokine Production in Intestinal Epithelial Cells by IL-17A and IL-17F
- Erythropoietin Signaling
- FXR/RXR Activation
- Glucocorticoid Receptor Signaling
- Graft-versus-Host Disease Signaling
- Hematopoiesis from Pluripotent Stem Cells
- Hepatic Cholestasis
- IL-1 Signaling
- IL-6 Signaling
- LPS/IL-1 Mediated Inhibition of RXR Function
- LXR/RXR Activation
- NF-κB Signaling
- p38 MAPK Signaling
- PPAR Signaling
- Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza
- Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses
- STAT3 Pathway
- Toll-like Receptor Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- COVID-19
- infection
- chronic kidney disease
- hyperplasia
- acne
- papillomatosis
- epithelial neoplasia
- benign neoplasia
- atopic dermatitis
role in cell
- binding in
- quantity
- expression in
- differentiation
- phosphorylation in
- binding
- induction in
- formation
- formation in
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- Nucleus
- Plasma Membrane
- cytosol
- apical cell surfaces
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IL1A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cell proliferation
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- cellular sodium ion homeostasis
- positive regulation of mitosis
- extrinsic apoptotic signaling pathway in absence of ligand
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of angiogenesis
- positive regulation of prostaglandin secretion
- heart development
- inflammatory response
- response to hypoxia
- cellular response to heat
- immune response
- positive regulation of cell division
- cytokine-mediated signaling pathway
- apoptotic process
- positive regulation of tumor necrosis factor production
- regulation of nitric-oxide synthase activity
- positive regulation of protein secretion
- response to gamma radiation
- positive regulation of steroid biosynthetic process
- positive regulation vascular endothelial growth factor production
- positive regulation of interleukin-2 production
- response to L-ascorbic acid
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
- germ cell programmed cell death
- spermatogenesis
- response to ozone
- response to copper ion
- positive regulation of immature T cell proliferation in thymus
- fever generation
- connective tissue replacement involved in inflammatory response wound healing
- regulation of actin cytoskeleton organization
- cellular response to lipopolysaccharide
- positive regulation of JNK cascade
- positive regulation of gene expression
- positive regulation of ERK1 and ERK2 cascade
- keratinization
- positive regulation of interleukin-6 production
- response to organic nitrogen
- positive regulation of cytokine production
- positive regulation of stress-activated MAPK cascade
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular space
- cytosol
- extracellular region
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- copper ion binding
- cytokine activity
- interleukin-1 receptor binding