RICTOR Gene Summary [Human]
RICTOR and MTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth (Sarbassov et al., 2004 [PubMed 15268862]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | RICTOR |
| Official Name | RPTOR independent companion of MTOR complex 2 [Source:HGNC Symbol;Acc:HGNC:28611] |
| Ensembl ID | ENSG00000164327 |
| Bio databases IDs | |
| Aliases | RPTOR independent companion of MTOR complex 2, rapamycin-insensitive companion of mTOR, pianissimo |
| Synonyms | 4921505C17Rik, 6030405M08Rik, AVO3, D530039E11Rik, hAVO3, KIAA1999, Mtorc2, PIA, RPTOR independent companion of MTOR complex 2, RPTOR independent companion of MTOR, complex 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RICTOR often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase binding
- ATP binding
- protein binding activity, bridging
- protein binding
- Rapamycin-insensitive companion of mTOR, middle domain
- threonine phosphorylation site
- phosphorylation site
- protein kinase activator
- Rapamycin-insensitive companion of mTOR, phosphorylation-site
- zinc ion binding
- Rapamycin-insensitive companion of mTOR, domain 5
- Rapamycin-insensitive companion of mTOR, N-term
- ribosome binding
- Rapamycin-insensitive companion of mTOR RasGEF_N domain
Pathways
Biological processes and signaling networks where the RICTOR gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- pancreatic adenocarcinoma
- metastasis
- colorectal cancer
- epithelial neoplasia
- hereditary disorder
- female infertility
- pancreatic ductal adenocarcinoma
- pancreatic epithelial cancer
- ductal pancreatic cancer
role in cell
- proliferation
- apoptosis
- activation in
- adhesion
- expression in
- differentiation
- activation
- migration
- generation in
- replication in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- high-density microsomal fractions
- low-density microsomal fraction
- apical ectoplasmic specialization
- Nucleus
- Plasma Membrane
- lysosome
- Endoplasmic Reticulum
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RICTOR gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytoskeleton organization
- embryo development ending in birth or egg hatching
- regulation of protein kinase B signaling cascade
- positive regulation of cell growth
- regulation of actin cytoskeleton organization
- cellular response to nutrient levels
- negative regulation of apoptotic process
- positive regulation of actin filament polymerization
- regulation of gene expression
- regulation of inflammatory response
- regulation of peptidyl-serine phosphorylation
- positive regulation of endothelial cell proliferation
- peptidyl-serine phosphorylation
- positive regulation of TOR signaling cascade
- actin cytoskeleton organization
- positive regulation of peptidyl-tyrosine phosphorylation
- positive regulation of protein kinase B signaling cascade
- regulation of establishment of cell polarity
Cellular Component
Where in the cell the gene product is active
- TORC2 complex
- cytosol
- Golgi apparatus
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein serine/threonine kinase activator activity
- protein binding
- ribosome binding
- binding, bridging