Slc15a2 Gene Summary [Mouse]
Enables dipeptide transmembrane transporter activity and high-affinity oligopeptide transmembrane transporter activity. Involved in several processes, including dipeptide import across plasma membrane; peptidoglycan transport; and regulation of nucleotide-binding activity domain, leucine rich repeat containing receptor signaling pathway. Acts upstream of or within oligopeptide transport. Located in plasma membrane. Is expressed in several structures, including genitourinary system; integumental system; nervous system; nose; and respiratory system. Orthologous to human SLC15A2 (solute carrier family 15 member 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc15a2 |
| Official Name | solute carrier family 15 (H+/peptide transporter), member 2 [Source:MGI Symbol;Acc:MGI:1890457] |
| Ensembl ID | ENSMUSG00000022899 |
| Bio databases IDs | |
| Aliases | solute carrier family 15 (H+/peptide transporter), member 2 |
| Synonyms | 8430408C16Rik, FLJ33407, PEPT2, solute carrier family 15 (H+/peptide transporter), member 2, solute carrier family 15 member 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc15a2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- amide transporter
- high affinity oligopeptide transporter
- transmembrane domain
- Major Facilitator Superfamily
- peptide:hydrogen symporter
- protein binding
- tripeptide transporter
- peptide:H+ symporter family
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- proximal tubular toxicity
- endometriosis
- allergic rhinitis
- multiple sclerosis
- eczema
- allergy
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- apical cell surfaces
- apical membrane
- brush border
- brush border membrane vesicles
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc15a2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ion transport
- renal absorption
- dipeptide transport
- protein transport
- regulation of nucleotide-binding oligomerization domain containing signaling pathway
- xenobiotic transport
- peptidoglycan transport
- peptide transport
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- membrane
- phagocytic vesicle membrane
- apical plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- dipeptide transmembrane transporter activity
- peptide:hydrogen symporter activity
- protein binding
- tripeptide transporter activity