Wt1 Gene Summary [Mouse]
This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It plays an essential role in the normal development of the urogenital system, and the orthologous human gene is mutated in a small subset of patients with Wilm's tumors. Alternative splicing has been noted for this gene, however, the full-length nature of these variants is not known. The mRNA for this gene has been shown to initiate translation from non-AUG (CUG) and AUG translation start sites, resulting in different isoforms. [provided by RefSeq, Apr 2013]
Details
| Type | Protein Coding |
| Official Symbol | Wt1 |
| Official Name | Wilms tumor 1 homolog [Source:MGI Symbol;Acc:MGI:98968] |
| Ensembl ID | ENSMUSG00000016458 |
| Bio databases IDs | |
| Aliases | Wilms tumor 1 homolog |
| Synonyms | D630046I19RIK, GUD, NPHS4, WAGR, wilms' tumour, wilms tumour 1, Wilms tumour-suppressor, Wilms' tumour suppressor, WIT-2, WT, WT1 transcription factor, WT33 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Wt1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- activation domain
- transcription regulator
- KTS motif (Lys-Thr-Ser)
- DNA binding domain
- suppression domain
- nucleic acid binding
- polyglycine repeat
- nuclear localization sequence
- transcription activation domain
- protein domain specific binding
- protein binding
- sequence-specific DNA binding
- proline rich domain
- Wilm's tumour protein
- transcription repression domain
- zinc ion binding
- double-stranded DNA binding
- Zinc-finger double domain
- zinc finger domain
- transcription factor activity
Pathways
Biological processes and signaling networks where the Wt1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- myelodysplastic syndrome
- non-insulin-dependent diabetes mellitus
- neoplasia
- breast cancer
- urogenital cancer
- abdominal cancer
- epithelial cancer
- epithelial neoplasia
- lung cancer
role in cell
- expression in
- binding in
- activation in
- proliferation
- survival
- cell death
- binding
- cell cycle progression
- quantity
- damage
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- perinuclear region
- cytosol
- nucleoplasm
- nuclear speckles
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Wt1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of metanephric ureteric bud development
- RNA splicing
- positive regulation of heart growth
- male gonad development
- positive regulation of male gonad development
- visceral serous pericardium development
- negative regulation of cell proliferation
- thorax and anterior abdomen determination
- cardiac muscle cell fate commitment
- sex determination
- vasculogenesis
- positive regulation of transcription from RNA polymerase II promoter
- regulation of organ formation
- negative regulation of transcription from RNA polymerase II promoter
- heart development
- metanephric S-shaped body morphogenesis
- cellular response to gonadotropin stimulus
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- kidney development
- negative regulation of cell growth
- posterior mesonephric tubule development
- camera-type eye development
- negative regulation of metanephric glomerular mesangial cell proliferation
- adrenal gland development
- metanephric epithelium development
- mesenchymal to epithelial transition
- germ cell development
- negative regulation of female gonad development
- regulation of transcription, DNA-dependent
- hypermethylation of CpG island
- diaphragm development
- tissue development
- regulation of transcription from RNA polymerase II promoter
- glomerular basement membrane development
- epithelial cell differentiation
- metanephric mesenchyme development
- glomerulus development
- gonad development
- ureteric bud development
- male genitalia development
- branching involved in ureteric bud morphogenesis
- positive regulation of gene expression
- glomerular visceral epithelial cell differentiation
- negative regulation of apoptotic process
- cellular response to cAMP
- adrenal cortex formation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nuclear speck
- cytosol
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- double-stranded methylated DNA binding
- sequence-specific DNA binding transcription factor activity
- zinc ion binding
- protein binding
- RNA binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- C2H2 zinc finger domain binding
- transcription regulatory region sequence-specific DNA binding
- sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity