Chrd Gene Summary [Mouse]
Enables BMP binding activity; heparin binding activity; and proteoglycan binding activity. Involved in several processes, including cell surface receptor signaling pathway; circulatory system development; and modulation of chemical synaptic transmission. Acts upstream of or within several processes, including gastrulation; negative regulation of osteoblast differentiation; and osteoblast differentiation. Located in extracellular space. Is active in cell surface and extracellular region. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and skeletal system. Used to study DiGeorge syndrome and velocardiofacial syndrome. Orthologous to human CHRD (chordin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Chrd |
| Official Name | chordin [Source:MGI Symbol;Acc:MGI:1313268] |
| Ensembl ID | ENSMUSG00000006958 |
| Bio databases IDs | |
| Aliases | chordin |
| Synonyms | Chd, chordin |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Chrd often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- von Willebrand factor type C domain
- cytokine binding
- binding protein
- CHRD domain
- syndecan binding
- protein binding
- heparin binding
- cysteine rich domain
Pathways
Biological processes and signaling networks where the Chrd gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- osteogenesis imperfecta type III
- holoprosencephaly
- androgenic alopecia
- tinnitus
- congenital heart disease
- cyclopia
role in cell
- proliferation
- cell death
- migration
- differentiation
- morphology
- organization
- invasion
- adhesion
- Clathrin mediated endocytosis by
- commitment
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Chrd gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of BMP signaling pathway
- skeletal system development
- BMP signaling pathway
- spinal cord dorsal/ventral patterning
- positive regulation of mesenchymal cell proliferation
- positive regulation of cell adhesion
- floor plate development
- negative regulation of cell migration
- dorsal/ventral pattern formation
- negative regulation of osteoblast differentiation
Cellular Component
Where in the cell the gene product is active
- extracellular space
Molecular Function
What the gene product does at the molecular level
- BMP binding
- protein binding
- cytokine binding