Btnl2 Gene Summary [Mouse]
Enables signaling receptor binding activity. Acts upstream of or within negative regulation of T cell receptor signaling pathway; positive regulation of T cell proliferation; and positive regulation of interleukin-2 production. Predicted to be located in membrane. Predicted to be active in external side of plasma membrane. Is expressed in intestine and skeletal muscle. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; autoimmune disease (multiple); berylliosis; coronary artery disease; and sarcoidosis. Orthologous to human BTNL2 (butyrophilin like 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Btnl2 |
| Official Name | butyrophilin-like 2 [Source:MGI Symbol;Acc:MGI:1859549] |
| Ensembl ID | ENSMUSG00000024340 |
| Bio databases IDs | |
| Aliases | butyrophilin-like 2 |
| Synonyms | Btl2, BTL-II, BTLN2, BTN7, butyrophilin-like 2, Gm315, HSBLMHC1, NG9, SS2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Btnl2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Immunoglobulin V-Type
- immunoglobulin domain
- Immunoglobulin like
- Immunoglobulin I-set domain
- protein binding
- receptor binding
- transmembrane receptor
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- primary biliary cirrhosis
- hypothyroidism
- colitis
- insulin-dependent diabetes mellitus
- weight loss
- multiple sclerosis
- Crohn disease
- osteoarthritis
- organismal death
- marginal zone cell lymphoma
role in cell
- expression in
- production in
- phosphorylation in
- proliferation
- differentiation
- inactivation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Btnl2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cytokine production
- T cell receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- receptor binding