Epc1 Gene Summary [Mouse]
Predicted to enable chromatin-protein adaptor activity. Predicted to be involved in double-strand break repair via homologous recombination; regulation of cell cycle; and regulation of nucleobase-containing compound metabolic process. Predicted to act upstream of or within negative regulation of gene expression, epigenetic; positive regulation of striated muscle cell differentiation; and regulation of transcription by RNA polymerase II. Predicted to be located in nuclear body; nuclear membrane; and nucleolus. Predicted to be part of NuA4 histone acetyltransferase complex; nucleosome; and piccolo histone acetyltransferase complex. Predicted to be active in site of double-strand break. Is expressed in several structures, including blood vessel endothelium; brain; heart; retina; and skeletal muscle. Orthologous to human EPC1 (enhancer of polycomb homolog 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Epc1 |
| Official Name | enhancer of polycomb homolog 1 [Source:MGI Symbol;Acc:MGI:1278322] |
| Ensembl ID | ENSMUSG00000024240 |
| Bio databases IDs | |
| Aliases | enhancer of polycomb homolog 1 |
| Synonyms | 2400007E14Rik, 5730566F07Rik, A930032N02Rik, enhancer of polycomb homolog 1, Epl1, mir-1893 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Epc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- Enhancer of polycomb-like
- protein binding activity, bridging
- Enhancer of Polycomb C-terminus
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- tumorigenesis
- peripheral T-cell lymphoma
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
- male pattern hair loss
- sexual disorder
- respiratory disorder
- endometrial stromal sarcoma
- endometrial sarcoma cancer
role in cell
- differentiation
- expression in
- binding in
- activation in
- formation
- multinucleation
- development
- cell cycle progression
- condensation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleosomes
- nucleoplasm
- nucleoli
- nuclear bodies
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Epc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of gene expression, epigenetic
- spermatid development
- transcription, DNA-dependent
- double-strand break repair via homologous recombination
- sperm chromatin condensation
- regulation of apoptotic process
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription, DNA-dependent
- regulation of double-strand break repair
- positive regulation of transcription, DNA-dependent
- regulation of cell cycle
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear membrane
- nuclear body
- site of double-strand break
- NuA4 histone acetyltransferase complex
- cytoplasm
- nucleosome
- Piccolo NuA4 histone acetyltransferase complex
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding