Dmap1 Gene Summary [Mouse]
Enables transcription corepressor activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in replication fork. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and integumental system. Orthologous to human DMAP1 (DNA methyltransferase 1 associated protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Dmap1 |
| Official Name | DNA methyltransferase 1-associated protein 1 [Source:MGI Symbol;Acc:MGI:1913483] |
| Ensembl ID | ENSMUSG00000009640 |
| Bio databases IDs | |
| Aliases | DNA methyltransferase 1-associated protein 1 |
| Synonyms | 1500016M21Rik, Dmtap1, DNA methyltransferase 1-associated protein 1, DNMAP1, DNMTAP1, EAF2, MEAF2, mKIAA1425, Mmtr, SWC4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dmap1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SANT
- transcription regulator
- transcription co-repressor
- nuclear localization sequence
- SANT/Myb-like domain of DAMP1
- DNA methyltransferase 1-associated protein 1 (DMAP1)
- transcription factor binding
- coiled-coil domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rotator cuff injury
- aldosterone producing adrenocortical adenoma
- adenoma formation
role in cell
- growth
- expression in
- activation in
- binding
- cell cycle progression
- replication in
- colony formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- cytosol
- centromeric region
- nuclear foci
- nucleosomes
- nucleoplasm
- DNA replication foci
- replication fork
- heterochromatic compartments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dmap1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- response to ethanol
- DNA repair
- chromatin remodeling
- positive regulation of protein import into nucleus
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- regulation of double-strand break repair
- regulation of transcription, DNA-dependent
- regulation of apoptotic process
- regulation of cell cycle
Cellular Component
Where in the cell the gene product is active
- replication fork
- nucleus
- NuA4 histone acetyltransferase complex
- cytoplasm
- Swr1 complex
- cytosol
- nucleosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- histone acetyltransferase activity
- protein binding
- transcription corepressor activity